ArticleResearch square2026
The human limbus functions as an instructive epithelial transition zone.
Yuzuru Sasamoto, Yoshiko Fukuda, Catherine Lee, Shuoshuo Wang, Sheethal Umesh, Shinri Sato, Kosei Suzuki, Shoko Kiritoshi, Ioannis Vlachos, Nick Di Girolamo and 2 more
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Yuzuru SasamotoDepartment of Ophthalmology, University of Washington.
Yoshiko FukudaDepartment of Ophthalmology, Boston University Chobanian & Avedisian School of Medicine.
Catherine LeeBrigham and Women's Hospital.
Sheethal UmeshSpatial Transcriptomics Unit, Beth Israel Deaconess Medical Center.
Shinri SatoDepartment of Ophthalmology, University of Washington.
Shoko KiritoshiDivision of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston.
Nick Di GirolamoUniversity of New South Wales.
Funding
Stem Cell Integral Membrane Transporter ABCB5 and Dermal RegenerationP01AG071463 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Christine Guo Lian · 2022 to 2026
$13.6MABCB5-positive stem cells for LSCD therapyR01EY025794 · NEI · BOSTON CHILDREN'S HOSPITAL · PI NATASHA Y FRANK, Markus H. Frank · 2016 to 2026
$6.1MMultipotent ABCB5-positive cell therapeutics for corneal diseaseR24EY028767 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI FRANK, MARKUS H., FRANK, NATASHA Y · 2018 to 2022
$5.9MThe role of BCAM-positive cells in central cornea, limbus and conjunctivaR01EY036399 · NEI · UNIVERSITY OF WASHINGTON · PI Yuzuru Sasamoto · 2024 to 2026
$2.3MSkin-Intrinsic Immunosuppressive Mesenchymal Stem Cells and aGVHDR01HL161087 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI FRANK, MARKUS H., FRANK, NATASHA Y · 2022 to 2025
$1.7MDevelopment of cell-free approaches to the treatment of limbal stem cell deficiencyR00EY031741 · NEI · UNIVERSITY OF WASHINGTON · PI SASAMOTO, YUZURU · 2023 to 2025
$689kThe role of limbal fibroblasts for the maintenance of limbal stem cellsR21EY035735 · NEI · UNIVERSITY OF WASHINGTON · PI SASAMOTO, YUZURU · 2024 to 2025
$468kDevelopment of cell-free approaches to the treatment of limbal stem cell deficiencyK99EY031741 · NEI · BRIGHAM AND WOMEN'S HOSPITAL · PI SASAMOTO, YUZURU · 2020 to 2021
$220kBLRD VA I01 BX006004NEI NIH HHS K99 EY031741NEI NIH HHS R00 EY031741NEI NIH HHS R01 EY025794NEI NIH HHS R01 EY036399NEI NIH HHS R21 EY035735NEI NIH HHS R24 EY028767NHLBI NIH HHS R01 HL161087NIA NIH HHS P01 AG071463RRD VA I01 RX000989
6 · The paper itselfAbstract
The corneal and conjunctival epithelia have traditionally been regarded as distinct lineages separated by the limbus, a specialized niche proposed to enforce irreversible corneal identity through a hierarchically organized limbal stem cell compartment
Identifiers
PMID42396502
PMCPMC13321265
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