ArticleResearch square2026
Cumulus Expansion and Oocyte Quality Across the Pubertal Transition in Mice: Implications for Modeling Fertility Preservation in Adolescents.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Objective: To determine whether cumulus expansion and oocyte aneuploidy differ across the pubertal transition in a murine model designed to approximate clinical assisted reproductive technology (ART) conditions. Methods: Controlled experimental animal study using prepubertal (D16-25), peripubertal (D26-35), and reproductively young adult CD-1 female mice (9 and 12 weeks old). Mice underwent gonadotropin stimulation to model controlled ovarian hyperstimulation. Cumulus-oocyte complexes (COCs) were collected following in vivo maturation prior to ovulation or assessed before and after in vitro maturation (IVM). Main outcome measures included COC surface area, cumulus cell layer thickness, oocyte spindle configuration, chromosome alignment, and aneuploidy rates. Results: Following in vivo maturation, COC surface area (1505 ± 151.4 μm Conclusion: In this murine model, markers of oocyte competence, including cumulus expansion, meiotic integrity, and aneuploidy rates, were largely preserved across the pubertal transition, highlighting translational limitations of mice for modeling human adolescent ovarian biology.
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