Evidence map›Paper›PMID 42396481›Full record

ArticleResearch square2026

Multiomic analysis reveals that polyamines alter G. vaginalis-induced cervicovaginal epithelial cell dysfunction.

Lauren Anton, Olha Kholod, Rutuja Phatate, Briana Ferguson, Kristin Klohonatz, Brittany A Goods, Kristin D Gerson

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lauren AntonUniversity of Pennsylvania.
Olha KholodDartmouth College.
Rutuja PhatateDartmouth College.
Briana FergusonUniversity of Pennsylvania.
Kristin KlohonatzUniversity of Pennsylvania.
Brittany A GoodsDartmouth College.
Kristin D GersonUniversity of Pennsylvania.

Funding

UNIVERSITY OF PENNSYLVANIA CAN CTR SUPPORT GRANTP30CA016520 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Robert H. Vonderheide · 1985 to 2026
$222.3M
Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
Zhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI MICHAEL L WHITFIELD · 2019 to 2026
$27.2M
Polyamine modification of host immune responses and oxidative balance in the cervicovaginal space: potential mechanisms governing cervical remodeling in preterm birthR01HD114611 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Kristin Ducrest Gerson · 2024 to 2026
$2.0M
NCI NIH HHS P30 CA016520NIAID NIH HHS P30 AI045008NICHD NIH HHS R01 HD114611NIGMS NIH HHS P20 GM130454
6 · The paper itself

Abstract

Background: An anaerobe-dominant, Results: We show microbe-specific alterations in cervicovaginal epithelial cell metabolite profiles where Conclusions: The ability of cervicovaginal metabolites to alter microbe-mediated changes in epithelial cell function suggests that metabolite-microbe interactions are critical mediators of epithelial defense against a

Indexed as

cervixepithelial cellsGardnerella vaginalisLactobacillus crispatusLuminexmetabolomicspolyaminesputrescineRNA-seqspermidinesperminetranscriptomicswomen’s health

Identifiers

PMID42396481
PMCPMC13321253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.