ArticleResearch square2026
Single nucleotide variant in coenzyme Q6 reprograms macrophage metabolic remodeling in response to inflammatory signals.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Macrophage metabolic remodeling sustains inflammatory responses to pathogens. At homeostasis, macrophages rely on oxidative phosphorylation (OXPHOS), but during inflammation, OXPHOS is downregulated and aerobic glycolysis increases. Increased flux through the tricarboxylic acid (TCA) cycle increases the availability of substrates, such as succinate, that promote pro-inflammatory transcription. While metabolic remodeling has been extensively characterized, the mechanisms governing the shift from OXPHOS to glycolysis remain unclear. We recently identified a single nucleotide variant (SNV) in a mitochondrial protein, coenzyme Q6 (COQ6), that accelerates OXPHOS downregulation during infection with the Gram-positive organism
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