ArticleFrontiers in immunology2026
PIGL promotes the docetaxel resistance of prostate cancer and is regulated by E3 ubiquitin ligase HUWE1.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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- Erratum issued
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8 authors.
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Abstract
Introduction: The mechanism related to docetaxel resistance in PCa has not been fully elucidated, and in-depth study of the specific mechanism of docetaxel resistance in PCa is of great clinical significance for the treatment of PCa. Methods: We explored the expression level of PIGL and HUWE1 using TCGA database and our clinical sample. CCK8 assay, Transwell assay, colony formation assay, wound-healing assay were used to explore the role of HUWE1/PIGL. Ubiquitination assay and Co-immunoprecipitation assay were used to investigate the molecular mechanism. Results: We found that both the mRNA and protein of PIGL is highly expressed in prostate cancer (PCa) and associated with poor prognosis. The protein rather than mRNA of PIGL is highly expressed in docetaxel-resistant PCa and associated with prognosis in patients receiving docetaxel-based chemotherapy. High expression level of PIGL promotes the proliferation, migration, invasion, and docetaxel resistance of PCa cells Discussion: These findings emphasized the vital role of PIGL in the progression and docetaxel resistance of PCa and the effect of the E3 ubiquitin ligase HUWE1 on regulating the protein expression of PIGL.
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