ArticleInternational journal of applied & basic medical research
Association of Melanocortin-4 Receptor Single Nucleotide Polymorphisms rs2331841 and rs12970134 with Metabolically Unhealthy Obesity in a North Indian Cohort.
Article in International journal of applied & basic medical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Obesity is a global epidemic with diverse metabolic outcomes, categorized as metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). Genetic variations in the MC4R gene are known to be key to energy homeostasis, making it a critical candidate for explaining this metabolic heterogeneity. Aim: This study aimed to investigate the genetic basis of metabolically unhealthy obesity (MUHO) in a North Indian population from the Jammu region, specifically focusing on the association between polymorphisms (Single Nucleotide Polymorphisms [SNPs]) within the Melanocortin-4 Receptor (MC4R) gene and the predisposition to MUHO. Materials and Methods: We analyzed a cohort of 846 adult participants from the North Indian population of the Jammu region. The participants were divided into three groups: MUHO ( Results: Our findings revealed a statistically significant association between the "A" risk alleles of both MC4R SNPs and an increased predisposition to MUHO. The "A" allele of rs2331841 conferred a 1.75-fold increased risk for MUHO compared to MH-NW ( Conclusion: These results indicate that genetic variations in the MC4R gene contribute to the metabolic heterogeneity of obesity. Identifying these specific genetic markers is crucial for early risk stratification and developing personalized preventive strategies against obesity-related metabolic disorders.
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