Evidence map›Paper›PMID 42396337›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Large-scale functional annotation establishes a reference framework for human

Anthea Cheung, Neringa Pratuseviciute, Kirsten Black, Pawel Lis, Toan Phung, Melanie Cavin, Gabriel Morel, Anna Saari, Vincent Huin, Simone Zittel-Dirks and 18 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Anthea CheungMedical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0009-0000-5969-6215
Neringa PratuseviciuteMedical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0000-0002-1124-8699
Kirsten BlackMedical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0009-0006-1356-4560
Pawel LisMedical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0000-0002-4978-7671
Toan PhungMedical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0000-0002-2964-6070
Melanie CavinMedical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0009-0003-5530-7675
Gabriel MorelMedical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0009-0003-3001-1886
Anna SaariMedical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
Vincent HuinUniversity of Lille, Inserm, CHU Lille, U1172 - LilNCog (JPARC) - Lille Neurosciences & Cognition, F-59000 Lille, France.ORCID 0000-0001-8201-5406
Simone Zittel-DirksDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.ORCID 0000-0002-3767-6376
Francesca TonelliMedical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0000-0002-4600-6630
Benjamin RiebenbauerDepartment of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, 72076, Germany.
Thomas GasserDepartment of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, 72076, Germany.ORCID 0000-0002-1069-1146
Javier Ruiz-MartinezDepartment of Neurology, Donostia University Hospital, Biogipuzkoa Health Research Institute, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), San Sebastián ES 20014, Spain.ORCID 0000-0001-7326-6270
Global Parkinson’s Genetics Program (GP2)
Huw R MorrisDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.ORCID 0000-0002-5473-3774
Lara M LangeMolecular Genetics Section, Laboratory of Neurogenetics, National Institute on Aging, and National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-7162-9821
Allison DilliottPD GENEration, Parkinson's Foundation, Miami, FL 33126, USA.ORCID 0000-0003-3863-9304
Orly GoldsteinThe Laboratory of Biomarkers and Genomics of Neurodegeneration, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.ORCID 0000-0001-7781-2734
Shachar ShaniThe Laboratory of Biomarkers and Genomics of Neurodegeneration, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.
Lionel ArnaudDépartement de Génétique Médicale, APHP Sorbonne Université, Paris 75013, France.
Alexander ZimprichDepartment of Neurology, Medical University of Vienna, Vienna 1090, Austria.ORCID 0000-0002-1668-5177
Walter PirkerDepartment of Neurology, Klinik Ottakring, Wiener Gesundheitsverbund, Vienna 1160, Austria.ORCID 0000-0002-9729-9728
Christine KleinInstitute of Neurogenetics, University of Lübeck, Lübeck 23562, Germany.ORCID 0000-0003-2102-3431
Roy AlcalayThe Laboratory of Biomarkers and Genomics of Neurodegeneration, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.ORCID 0000-0002-5717-4875
Katja LohmannInstitute of Neurogenetics, University of Lübeck, Lübeck 23562, Germany.
Dario R AlessiMedical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0000-0002-2140-9185
Esther SammlerMedical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.ORCID 0000-0003-3218-7116

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic variants in leucine-rich repeat kinase 2 (

Indexed as

functional annotationkinaseoverexpression assaypathogenicity classificationprotein conservationProtein phosphorylationRab10

Identifiers

PMID42396337
PMCPMC13321175

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.