ArticlemedRxiv : the preprint server for health sciences2026
Survival differences and artemisinin resistance in severe malaria among HIV coinfected patients: data from Mozambique.
Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Malaria remains a significant cause of morbidity and mortality, especially in sub-Saharan Africa, where rates of HIV coinfection are high. This study aimed to determine whether Methodology: We conducted an observational study of non-pregnant adults, with and without HIV coinfection, admitted to the Hospital Central de Maputo for treatment of severe malaria. Results: We recruited 149 study participants aged between 18-62 years, 72 (48.3%) were female, and 59 (39.6%) were infected with HIV. Comparing clinical outcomes, we found a significant difference in anemia (hemoglobin <5 mg/dl: P-value = 0.01248) but no other predefined clinical characteristics including fever, renal dysfunction, or pulmonary edema in those with and without HIV coinfection. We found significantly higher in hospital mortality in those with HIV coinfection ( Conclusions: We find a higher mortality rate in patients with malaria-HIV coinfection, further emphasizing the importance of effective treatment for this vulnerable population. We also provide an important baseline for the rate of resistance-conferring mutations in a population at risk of harboring resistant parasites in Mozambique, highlighting the need for continued surveillance.
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