Evidence map›Paper›PMID 42396287›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Local and circulating cytotoxic CD4

Veronika Niederlova, Kyle Kimler, Hengqi Betty Zheng, Marc Elosua Bayes, Rose Hedderman, Paula Keskula, Iva Pacakova, Jan Vecek, Joshua de Sousa Casal, Andrew Kwong and 20 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Veronika NiederlovaDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0001-8768-9039
Kyle KimlerDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-4735-9064
Hengqi Betty ZhengDivision of Gastroenterology and Hepatology, Seattle Children's Hospital and University of Washington, Seattle, WA 98105, USA.ORCID 0000-0003-0575-6475
Marc Elosua BayesDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.
Rose HeddermanDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.
Paula KeskulaDivision of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-0458-9153
Iva PacakovaDepartment of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.
Jan VecekDepartment of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.
Joshua de Sousa CasalDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-2006-3992
Andrew KwongDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.
Leonard NetteyRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.ORCID 0000-0002-0387-9327
Zoë SteierRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.ORCID 0000-0003-1488-7995
Katarína KováčováDepartment of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.
Brandi BratrudeDivision of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.
Jillian ZavistaskiDivision of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.
Wei Keat LimRegeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.ORCID 0000-0002-6226-2570
Andrea T HooperRegeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.ORCID 0000-0003-1131-1229
Scott MacDonnellRegeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
Nathalie FiaschiRegeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
Zaruhi HovhannisyanRegeneron Pharmaceuticals Inc., Tarrytown, NY 10591, USA.
Ghassan WahbehDivision of Gastroenterology and Hepatology, Seattle Children's Hospital and University of Washington, Seattle, WA 98105, USA.
David SuskindDivision of Gastroenterology and Hepatology, Seattle Children's Hospital and University of Washington, Seattle, WA 98105, USA.
Lusine AmbartsumyanDivision of Gastroenterology and Hepatology, Seattle Children's Hospital and University of Washington, Seattle, WA 98105, USA.
Dale LeeDivision of Gastroenterology and Hepatology, Seattle Children's Hospital and University of Washington, Seattle, WA 98105, USA.
Jan DobešDepartment of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.ORCID 0000-0003-1853-1603
Scott B SnapperDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-0267-4247
Ondrej StepanekLaboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, 142 20, Czech Republic.ORCID 0000-0002-2735-3311
Alex K ShalekRagon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.ORCID 0000-0001-5670-8778
Leslie S KeanDivision of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-0475-3926
Jose Ordovas-MontanesDivision of Gastroenterology, Hepatology, and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0001-5444-5601

Funding

Transplant Tolerance in Non-Human PrimatesU19AI051731 · NIAID · UNIVERSITY OF WESTERN ONTARIO · PI LARSEN, CHRISTIAN P. · 2002 to 2022
$54.1M
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Novel Biologic Therapies for GVHDR01HL095791 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI KEAN, LESLIE S · 2010 to 2025
$13.3M
Project 3: Enhanced Costimulation Blockade to Achieve Clinically Relevant Heart Allograft ToleranceP01HL158504 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI PIERSON, RICHARD N · 2021 to 2025
$12.1M
Identifying Immune and Epithelial Network Signatures in Very Early Onset Inflammatory Bowel DiseaseRC2DK122532 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI KLEIN, CHRISTOPH, MUISE, ALEIXO M · 2020 to 2024
$9.1M
Initiation of immune responses to SARS COV2 in the oral cavity and upper airwayR01DE031928 · NIDCR · UNIVERSITY OF MISSISSIPPI MED CTR · PI GILL DIAMOND, SARAH C GLOVER · 2022 to 2026
$3.8M
Balancing epithelial cell resistance and resilience to respiratory viral infectionsR01HL162642 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Jose Manuel Ordovas-Montanes · 2023 to 2026
$3.4M
An integrated multiplexed genomic assay for low input clinical samples1U24AI118672 · NIAID · BROAD INSTITUTE, INC. · PI SHALEK, ALEX K · 2015 to 2019
$2.0M
NHLBI NIH HHS P01 HL158504NHLBI NIH HHS R01 HL095791NHLBI NIH HHS R01 HL162642NIAID NIH HHS U19 AI051731NIAID NIH HHS U24 AI118672NIDCR NIH HHS R01 DE031928NIDDK NIH HHS P30 DK034854NIDDK NIH HHS RC2 DK122532NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273Wellcome Trust
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) burden is rising globally, yet only subsets of patients benefit from available therapies, underscoring the need for more precise molecular and cellular stratification. In the PREDICT study, we enrolled treatment-naïve pediatric patients with IBD, alongside disorders of gut-brain interaction (DGBI) controls and healthy donors, and profiled their intestinal and blood-derived T cells using single-cell RNA sequencing (scRNA-seq). Across 107 participants, we identify a unique population of cytotoxic CD4

Indexed as

Crohn’s diseasecytotoxic CD4 T cellsTNF therapyulcerative colitis

Identifiers

PMID42396287
PMCPMC13320927

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.