Evidence map›Paper›PMID 42396284›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Systemic and Mucosal Antibody Correlates of Protection Against Bordetella pertussis in a Controlled Human Infection Model.

Mehak Zahoor Khan, Yogita Kapoor, Evgenii Kliuchnikov, Thendral Selvam, Agness E Lakudzala, Laura Fontana, MaryBeth Culp, Susan Hariri, May Elsherif, Doug Lauffenburger and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mehak Zahoor KhanRagon Institute of Mass General, MIT and Harvard; Cambridge, MA, USA.ORCID 0000-0002-2780-4119
Yogita KapoorRagon Institute of Mass General, MIT and Harvard; Cambridge, MA, USA.ORCID 0000-0001-8543-1755
Evgenii KliuchnikovDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-2410-2138
Thendral SelvamRagon Institute of Mass General, MIT and Harvard; Cambridge, MA, USA.
Agness E LakudzalaMalawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Laura FontanaRagon Institute of Mass General, MIT and Harvard; Cambridge, MA, USA.
MaryBeth CulpCenters for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, Atlanta, Georgia, USA.
Susan HaririCenters for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, Atlanta, Georgia, USA.
May ElsherifCanadian Center for Vaccinology (Dalhousie University, IWK Health and Nova Scotia Health), 5850 University Avenue, Halifax, NS B3K 6R8, Canada.
Doug LauffenburgerDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-0050-989X
Scott HalperinCanadian Center for Vaccinology (Dalhousie University, IWK Health and Nova Scotia Health), 5850 University Avenue, Halifax, NS B3K 6R8, Canada.
Marcela F PasettiCenter for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-0894-4009
Galit AlterRagon Institute of Mass General, MIT and Harvard; Cambridge, MA, USA.ORCID 0000-0002-9221-6735
Boris JulgRagon Institute of Mass General, MIT and Harvard; Cambridge, MA, USA.ORCID 0000-0002-4687-9626

Funding

Research Project 2 The pregnancy AdaptOMEU19AI167899 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DOUGLAS A LAUFFENBURGER · 2022 to 2026
$14.7M
NIAID NIH HHS U19 AI167899
6 · The paper itself

Abstract

Background: Despite high vaccination coverage, pertussis has resurged globally. Whole-cell (wP) and acellular (aP) pertussis vaccines induce distinct immune profiles, yet immune correlates of protection against infection and symptomatic disease remain incompletely defined. We leveraged a controlled human infection model (CHIM) to identify systemic and mucosal humoral signatures associated with resistance to Methods: Adults with documented history of vaccination had previously been enrolled in a CHIM study and challenged intranasally with Findings: Baseline aP vaccine antigen-specific antibodies did not distinguish infection outcomes. In wP-primed individuals, protection from Interpretation: Resistance to infection was largely restricted to wP-primed individuals and was associated with integrated systemic and mucosal antibody responses directed against antigens beyond those included in acellular vaccines. Protection from symptomatic disease in both vaccine groups was linked to distinct antibody response signatures, shaped by prior vaccination history. These findings indicate that immune mechanisms preventing infection differ from those limiting clinical disease and provide a framework for redesign of next-generation pertussis vaccines aimed at blocking infection and symptomatic disease.

Indexed as

AntibodiesBordetella pertussiscorrelates of protectionFc effector functionHumoral immunitySystems serologyVaccine antigens

Identifiers

PMID42396284
PMCPMC13321178

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.