Evidence map›Paper›PMID 42396247›Full record

ArticleJournal of intensive medicine2026

The OxyCam: A novel hand-held vital microscope for quantitative measurement of microcirculatory perfusion and oxygenation.

Can Ince, Bülent Ergin, Jonathan Montomoli, Mario Döring, Noor Boegborn, Wijnie van Dam, Giovanny Marchena, Olcay Dilken, Arie de Vos, Husain Khaki and 2 more

Abstract read
In one paragraph

Article in Journal of intensive medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Can InceThe Department of Intensive Care, Laboratory of Emeregency, Perioperative and Intensive Care (EPIC lab), Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Bülent ErginThe Department of Intensive Care, Laboratory of Emeregency, Perioperative and Intensive Care (EPIC lab), Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Jonathan MontomoliDepartment of Anaesthesia and Intensive Care, Infermi Hospital, Romagna Local Health Authority, Rimini, Italy.
Mario DöringUniversity Hospital of Zurich, Institute of Intensive Care Medicine, Zurich, Switzerland.
Noor BoegbornThe Department of Intensive Care, Laboratory of Emeregency, Perioperative and Intensive Care (EPIC lab), Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Wijnie van DamThe Department of Intensive Care, Laboratory of Emeregency, Perioperative and Intensive Care (EPIC lab), Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Giovanny MarchenaThe Department of Intensive Care, Laboratory of Emeregency, Perioperative and Intensive Care (EPIC lab), Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Olcay DilkenThe Department of Intensive Care, Laboratory of Emeregency, Perioperative and Intensive Care (EPIC lab), Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Arie de VosActive Medical B.V., Leiden, The Netherlands.
Husain KhakiActive Medical B.V., Leiden, The Netherlands.
Diederik GommersThe Department of Intensive Care, Laboratory of Emeregency, Perioperative and Intensive Care (EPIC lab), Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Matthias Peter HiltyActive Medical B.V., Leiden, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hand-Held Vital Microscopy (HVM) has been utilized in clinical investigations to measure microcirculation, providing valuable insights into the pathophysiology of critical illness and its treatment. However, its clinical implementation has been hampered by several shortcomings. These included the need for automatic analysis software, for instant image stabilization, and for information regarding microcirculatory oxygenation. The aim of this study is to describe an HVM which has realized these research objectives. Methods: This preclinical study introduces the OxyCam, a novel HVM device. OxyCam stabilizes images during recording and subsequently provides essential microcirculatory functional parameters through automatic analysis. Green and blue illuminated images, sequentially recorded and ratio imaged, allow calculation of the hemoglobin (Hb) oxygen saturation (µHbO Results: Green and blue illumination from the OxyCam yielded higher total vessel density (OxyCam green [31.4±4.3] mm/mm Conclusions: The OxyCam has been validated for measuring tissue perfusion and oxygenation and can be considered for point-of-care diagnosis of the microcirculation at the bedside.

Indexed as

CytocamOxyCamSpectrophotometrySublingualTissue oxygenationTissue perfusion

Identifiers

PMID42396247
PMCPMC13323549

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.