ArticleFrontiers in medicine2026
Neutrophil-to-lymphocyte ratio is associated with early cervical shortening after cerclage: a single-center cohort study integrating C-reactive protein.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to explore whether pre-operative systemic inflammatory markers-neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP)-are associated with early post-cerclage cervical shortening and to examine whether atosiban use varied according to inflammatory status in this retrospective cohort. Methods: A single-center retrospective cohort study conducted in 2023 included 84 singleton pregnancies that underwent McDonald cerclage. Full blood count and CRP were measured within 24 h before surgery. The primary outcomes were (i) the cervical length (CL) shortening rate (mm/week) up to 28 weeks' gestation and (ii) spontaneous preterm birth before 32 weeks' gestation. Atosiban was administered at the attending physician's discretion to women with threatened preterm labor or recurrent uterine contractions, not by random allocation. Treatment allocation was non-random and susceptible to confounding by indication. Results: NLR correlated linearly with CL shortening ( Conclusion: In this small (
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