Evidence map›Paper›PMID 42396143›Full record

ArticleFrontiers in medicine2026

Differentiating effective salvage from ineffective delayed compensation in anterior circulation stroke: a dynamic quantitative collateral index.

Zhong Zheng, Ailixier Tayier, Dayu Wu, Weiping Lu, Ziying Wang, Tong Hou, Hongqing Zhu, Ying Wang, Bingcang Huang

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zhong ZhengPostgraduate Training Base at Shanghai Gongli Hospital, Ningxia Medical University, Shanghai, China.
Ailixier TayierPostgraduate Training Base at Shanghai Gongli Hospital, Ningxia Medical University, Shanghai, China.
Dayu WuDepartment of Neurology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China.
Weiping LuDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China.
Ziying WangSchool of Information Science and Engineering, East China University of Science and Technology, Shanghai, China.
Tong HouSchool of Information Science and Engineering, East China University of Science and Technology, Shanghai, China.
Hongqing ZhuSchool of Information Science and Engineering, East China University of Science and Technology, Shanghai, China.
Ying WangShanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, Sino-French Cooperative Central Lab, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China.
Bingcang HuangDepartment of Radiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To investigate a deconvolution-free Dynamic Quantitative Collateral Approach based on 4D-CTA reconstructed from CTP source data, and to evaluate its prognostic value for Early Neurological Recovery (ENR) in acute anterior circulation large vessel occlusion (LVO) by differentiating effective tissue salvage from ineffective delayed perfusion. Methods: In this retrospective study of 94 patients with anterior circulation LVO, the Rapid Compensation Index (RCI), Late Compensation Index (LCI), and Total Compensation Index (TCI) were calculated based on Vessel Volume Deficit (VVD) derived from 4D-CTA reconstructed from CTP source data. Logistic regression, ROC analysis, and Akaike Information Criterion (AIC) were utilized to compare the quantitative collateral indices against visual scores (Tan, rLMC, Menon) for predicting ENR (7-day ΔNIHSS ≥4). A predictive nomogram was constructed and evaluated for clinical net benefit. Results: RCI significantly predicted recovery, whereas LCI showed limited utility, objectively reflecting delayed collateral filling. TCI independently predicted ENR with high discrimination (AUC = 0.858), significantly outperforming the Tan score (AUC = 0.810, Conclusion: This dynamic approach provides an objective, deconvolution-free assessment of hemodynamic efficiency. By physiologically distinguishing functional reperfusion from ineffective delayed compensation, it demonstrates prognostic accuracy comparable to expert consensus, offering a robust tool for acute stroke triage.

Indexed as

collateral circulationcomputed tomography perfusionearly neurological recoveryhemodynamicsischemic stroke

Identifiers

PMID42396143
PMCPMC13322897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.