ArticleFrontiers in medicine2026
Prognostic value of the aggregate index of systemic inflammation and controlling nutritional status score for all-cause mortality in patients undergoing maintenance hemodialysis: a retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study investigated the prognostic relevance of the Controlling Nutritional Status (CONUT) score and the Aggregate Index of Systemic Inflammation (AISI) for predicting all-cause mortality (ACM) in patients undergoing maintenance hemodialysis (MHD). Furthermore, the study aimed to identify independent prognostic indicators to aid clinical risk categorization and tailored therapeutic interventions. Methods: A retrospective cohort study was performed with a follow-up duration of 5 years. Extensive demographic data and clinical laboratory results were gathered, and patients were followed until December 2024, with ACM set as the principal endpoint. The predictive capabilities of the CONUT score and AISI for ACM among MHD patients were evaluated by receiver operating characteristic (ROC) curve analysis. Survival outcomes were depicted through Kaplan-Meier curves, and Cox proportional hazards regression was utilized to ascertain significant prognostic factors for five-year ACM. Results: In total, 614 patients on MHD were enrolled. ROC analysis yielded areas under the curve (AUC) of 0.704 for the CONUT score and 0.694 for AISI, with optimal threshold values identified at 3.5 and 306.100, respectively. Patients exhibiting AISI below 306.100 had markedly better cumulative survival rates ( Conclusion: Both AISI and the CONUT score provide significant prognostic information for predicting ACM in patients undergoing MHD. Their combined use constitutes a robust, accessible tool for identifying high-risk individuals in this population.
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