ArticleACS omega2026
Broad-Spectrum Antimicrobial Activity of a Ruthenium(II) Polypyridyl Complex against Multidrug-Resistant Uropathogens and Biofilms.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
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Abstract
Antimicrobial resistance and biofilm persistence are major barriers to treating device-associated infections, including catheter-associated urinary tract infections. We evaluated KLS-116, a ruthenium-(II) polypyridyl complex, as a next-generation antimicrobial with broad activity against multidrug-resistant uropathogens. KLS-116 showed potent bactericidal effects under physiologically relevant conditions, with minimum inhibitory concentrations ≤ 25 μM (41.8 mg/L) across diverse species. Checkerboard assays demonstrated compatibility with standard antibiotics, yielding indifferent or additive interactions and no antagonism. Importantly, KLS-116 reduced mature biofilms in continuous-flow catheter models and in static models achieved complete clearance at ≥16× MIC after 24 h, outperforming colistin with prolonged exposure. Over 42 days, resistance evolution showed minimal sensitivity shifts, contrasting with rapid ciprofloxacin resistance, indicating a low propensity for resistance. Activity varied with pH, suggesting that the metabolic state influences efficacy. These results position KLS-116 as a promising candidate for CAUTI management and other biofilm-driven infections, guiding future delivery optimization and in vivo validation.
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