Evidence map›Paper›PMID 42396000›Full record

ArticleACS omega2026

Therapeutic Efficacy of 7‑Chloro-4-(phenylselanyl)quinoline against Oncological Pain Induced by Tumor Progression and Vincristine Treatment.

Ketlyn P da Motta, Vanessa M E da Rocha, Bruna S Pacheco, Tiago V Collares, Fabiana K Seixas, Joanna V Z Echenique, Mauro P Soares, Rhayane Tavares, Diego Alves, Nathalia S Pedra and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ketlyn P da MottaGraduate Program in Biochemistry and Bioprospecting, Preclinical and Translational Research Group on Pain and Chronic Diseases, Center for Chemical, Pharmaceutical, and Food Science, Federal University of Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
Vanessa M E da RochaGraduate Program in Biochemistry and Bioprospecting, Preclinical and Translational Research Group on Pain and Chronic Diseases, Center for Chemical, Pharmaceutical, and Food Science, Federal University of Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
Bruna S PachecoCellular and Molecular Oncology Research Group (GPO), CDTec, Federal University of Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
Tiago V CollaresCellular and Molecular Oncology Research Group (GPO), CDTec, Federal University of Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
Fabiana K SeixasCellular and Molecular Oncology Research Group (GPO), CDTec, Federal University of Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
Joanna V Z EcheniqueRegional Diagnostic Laboratory Faculty of Veterinary Medicine, Federal University of Pelotas, 96010-900 Pelotas, RS, Brazil.
Mauro P SoaresRegional Diagnostic Laboratory Faculty of Veterinary Medicine, Federal University of Pelotas, 96010-900 Pelotas, RS, Brazil.
Rhayane TavaresGraduate Program in Chemistry, Clean Organic Synthesis Laboratory, Federal University of Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
Diego AlvesGraduate Program in Chemistry, Clean Organic Synthesis Laboratory, Federal University of Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
Nathalia S PedraGraduate Program in Biochemistry and Bioprospecting, Laboratory of Neurochemistry, Inflammation and Cancer, 96010-900 Pelotas, RS, Brazil.
Natália P BonaGraduate Program in Biochemistry and Bioprospecting, Laboratory of Neurochemistry, Inflammation and Cancer, 96010-900 Pelotas, RS, Brazil.
Roselia M SpanevelloGraduate Program in Biochemistry and Bioprospecting, Laboratory of Neurochemistry, Inflammation and Cancer, 96010-900 Pelotas, RS, Brazil.
Juliano S BarinDepartment of Food Science and Technology, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil.ORCID https://orcid.org/0000-0002-8351-3287
Pricila N PinheiroGraduate Program in Biochemistry and Bioprospecting, Preclinical and Translational Research Group on Pain and Chronic Diseases, Center for Chemical, Pharmaceutical, and Food Science, Federal University of Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
Vinicius C PradoGraduate Program in Biochemistry and Bioprospecting, Preclinical and Translational Research Group on Pain and Chronic Diseases, Center for Chemical, Pharmaceutical, and Food Science, Federal University of Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.
Marcia F MeskoContaminant Control Laboratory in Biomaterials (LCCBio Federal University of Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.ORCID https://orcid.org/0000-0002-7399-446X
Ethel A WilhelmGraduate Program in Biochemistry and Bioprospecting, Preclinical and Translational Research Group on Pain and Chronic Diseases, Center for Chemical, Pharmaceutical, and Food Science, Federal University of Pelotas (UFPel), 96010-900 Pelotas, RS, Brazil.ORCID https://orcid.org/0000-0002-2875-9962

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer pain is a complex condition often worsened by tumor progression and chemotherapy-induced neuropathy. This study evaluated the therapeutic potential of 7-chloro-4-(phenylselanyl)-quinoline (4-PSQ) in mice with Sarcoma 180 (S180)-induced cancer pain and vincristine (VCR)-induced peripheral neuropathy. Male mice were assigned to Control, S180, S180 + VCR, S180 + 4-PSQ, and S180 + VCR + 4-PSQ groups. S180 cells were injected intraplantarly on day 1; VCR was administered days 2-6, and 4-PSQ orally from days 8-17. Nociceptive behavior, tumor progression, and tissue biomarkers were assessed. S180 and VCR caused hyperalgesia, tumor edema, oxidative imbalance, and impaired Na

Identifiers

PMID42396000
PMCPMC13325082

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.