Evidence map›Paper›PMID 42395993›Full record

ArticleACS omega2026

Quantification of the Kynurenine Biomarker in Saliva Using Smatphone-Based Fluorescence Digital Imaging.

José Gouveia da Silva Neto, Luís Vinícius Gonçalves de Melo, José Ailton Mota Nascimento, Helayne S de Sousa, João Paulo de Almeida, Severino Carlos Oliveira, Vagner Bezerra Dos Santos

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PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

José Gouveia da Silva NetoDepartment of Fundamental Chemistry, Federal University of Pernambuco, Av. Jornalista Anibal Fernandes, S/N, Cidade Universitária, Recife, Pernambuco 50740-560, Brazil.
Luís Vinícius Gonçalves de MeloDepartment of Fundamental Chemistry, Federal University of Pernambuco, Av. Jornalista Anibal Fernandes, S/N, Cidade Universitária, Recife, Pernambuco 50740-560, Brazil.
José Ailton Mota NascimentoDepartment of Chemistry, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, S/N, Dois Irmãos, Recife, Pernambuco 52171-900, Brazil.ORCID https://orcid.org/0009-0005-6467-7875
Helayne S de SousaDepartment of Fundamental Chemistry, Federal University of Pernambuco, Av. Jornalista Anibal Fernandes, S/N, Cidade Universitária, Recife, Pernambuco 50740-560, Brazil.
João Paulo de AlmeidaDepartment of Fundamental Chemistry, Federal University of Pernambuco, Av. Jornalista Anibal Fernandes, S/N, Cidade Universitária, Recife, Pernambuco 50740-560, Brazil.
Severino Carlos OliveiraDepartment of Chemistry, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, S/N, Dois Irmãos, Recife, Pernambuco 52171-900, Brazil.
Vagner Bezerra Dos SantosDepartment of Fundamental Chemistry, Federal University of Pernambuco, Av. Jornalista Anibal Fernandes, S/N, Cidade Universitária, Recife, Pernambuco 50740-560, Brazil.ORCID https://orcid.org/0000-0002-9426-6197

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L-tryptophan (Trp) is an essential amino acid whose metabolism produces biologically relevant compounds such as serotonin, melatonin, kynurenine (Kyn), kynurenic acid (Kyna), and nicotinamide adenine dinucleotide (NAD+). Alterations in kynurenine pathway metabolism have been associated with several neurological and neurodegenerative disorders. Due to this importance, this study presents a fluorescence digital image-based (FDIB) analytical method for the quantification of kynurenine (Kyn) using a smartphone. The method is based on the derivatization reaction of Kyn with dansyl chloride (DNS-Cl), since the Kyn-DNS product exhibits high fluorescence when excited at 365 ± 50 nm. Thus, a UV-LED chamber was fabricated on a 3D printer, and it was used for excitation, as well as for capturing the fluorescence of Kyn-DNS using a smartphone, leading to the Kyn-DNS/3Dchamber/FDIB analytical method. The proposed method showed a linear range from 0.50 to 7.00 μmol L

Identifiers

PMID42395993
PMCPMC13325347

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.