ArticleACS omega2026
Surface Engineering of Magnetite Nanoparticles with Boronated Polysaccharides Enables Alpha-1-Acid Glycoprotein Binding.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycoproteins play essential roles in numerous biological processes, yet their controlled interaction with synthetic materials remains challenging due to structural complexity and heterogeneity of glycan moieties. In this study, starch-based magnetic nanomaterials functionalized with phenylboronic acid were developed and evaluated for pH-dependent interactions with α-1-acid glycoprotein (AGP). Dialdehyde starch (DAS) and carboxymethyl starch (CMS) were functionalized with phenylboronic acid to obtain DAS-PBA and CMS-PBA, which were subsequently used as coatings for magnetite nanoparticles, yielding the corresponding magnetic nanocomposites. The polymers and nanocomposites were comprehensively characterized using spectroscopic, microscopic, and thermal techniques. The functional accessibility of boronic acid groups was assessed using an Alizarin Red S assay. Binding studies demonstrated pH-dependent interactions with AGP, with enhanced binding observed under alkaline conditions, consistent with the behavior of boronic acid-diol interactions. Among the investigated systems, CMS-PBA-based materials exhibited higher AGP binding capacities compared to DAS-PBA-based analogues. Furthermore, partial release of AGP from the magnetic nanocomposites was achieved under mildly acidic conditions, confirming the reversible nature of the interactions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.