ArticleACS omega2026
High-Load Amino Acid Nanoemulsion: Physicochemical Optimization and Dermal Bioactivity.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
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Abstract
Amino acids such as GABA, glycine, and proline play critical roles in extracellular matrix renewal, but their high hydrophilicity limits dermal delivery. This study aimed to develop a stable oil-in-water nanoemulsion capable of incorporating a high amino acid load (20% w/w) and to evaluate its biological activity. Nanoemulsions were prepared using high-pressure homogenization at varying surfactant concentrations (5-7% w/w) and pressures (80-120 MPa). Physicochemical properties, stability, and amino acid content were evaluated, and biological activity was assessed in fibroblasts. The selected formulation (5% surfactant, 120 MPa), identified based on a balance of droplet size, stability, and biological response, showed improved stability and retained >95% of actives over 12 weeks. It significantly enhanced collagen and elastin gene expression. These findings demonstrate that process optimization enables stable high-load amino acid nanoemulsions with potential applications in dermal delivery.
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Registered trials
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