Rigorous Modeling and Industrial-Scalable Optimization of Hydroquinone-Catechol Vacuum Distillation: Aspen Plus-RSM Integration for Thermally Labile Systems.

Chenglei Wang, Yihong Zeng, Mingwu Yi, Mengqi Yang, Shusheng Qiu, Yuanjian Xie, Pingxiong Cai

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Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Chenglei WangGuangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou, Guangxi 535011, China.ORCID https://orcid.org/0009-0008-6938-4643

Yihong ZengShanghai Research Institute of Chemical Industry Company, Ltd., Shanghai 200062, China.

Mingwu YiGuangxi Huayi New Materials Company, Ltd., Qinzhou, Guangxi 535000, China.

Mengqi YangGuangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou, Guangxi 535011, China.

Shusheng QiuGuangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou, Guangxi 535011, China.

Yuanjian XieGuangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou, Guangxi 535011, China.ORCID https://orcid.org/0009-0000-8112-4336

Pingxiong CaiGuangxi Key Laboratory of Green Chemical Materials and Safety Technology, College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou, Guangxi 535011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To address the critical challenges of high energy consumption and low efficiency in conventional hydroquinone (HQ)-catechol (CAT) purification, this study presents a systematic computational investigation of vacuum distillation via Aspen Plus. Leveraging HQ and CAT's thermal sensitivity and nonazeotropic behavior (40.0 °C boiling point difference at 101.325 kPa), an accurate thermodynamic framework is built using the NRTL (non-random two-liquid) activity coefficient model, with parameters calibrated via UNIFAC and the Aspen database. A vacuum distillation configuration (column, condenser, reboiler) is initialized with 100 kg·h

Identifiers

PMID42395972

DOI10.1021/acsomega.6c03492

PMCPMC13325387

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.