Evidence map›Paper›PMID 42395957›Full record

ArticleACS omega2026

Biotinylated Diaryl Isoxazole Derivatives with Enhanced Janus Kinase 1 Inhibitory, Antiproliferative, and Apoptotic Activities in Cancer Cells.

Melike Ergüven, Hazal Beril Çatalak Yılmaz, Deniz Lengerli, Rana Acar, Servin Bagheralmoosavi, Yağmur Öykü Carus Şahin, Mehmet Gürçay, Burcu Çalışkan, Sreeparna Banerjee, Gurkan Yesiloz and 3 more

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Melike ErgüvenDepartment of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Türkiye.
Hazal Beril Çatalak YılmazDepartment of Biological Sciences, Orta Dogu Teknik Universitesi, Ankara 06800, Türkiye.ORCID https://orcid.org/0000-0003-3059-093X
Deniz LengerliDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara 06560, Türkiye.
Rana AcarDepartment of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Türkiye.ORCID https://orcid.org/0000-0001-6498-4342
Servin BagheralmoosaviNational Nanotechnology Research Center (UNAM) Bilkent University, Ankara 06800, Türkiye.
Yağmur Öykü Carus ŞahinDepartment of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Türkiye.ORCID https://orcid.org/0009-0008-3881-6140
Mehmet GürçayDepartment of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Türkiye.
Burcu ÇalışkanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara 06560, Türkiye.ORCID https://orcid.org/0000-0003-2391-5644
Sreeparna BanerjeeDepartment of Biological Sciences, Orta Dogu Teknik Universitesi, Ankara 06800, Türkiye.ORCID https://orcid.org/0000-0003-4596-6768
Gurkan YesilozNational Nanotechnology Research Center (UNAM) Bilkent University, Ankara 06800, Türkiye.
Ozlen KonuDepartment of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Türkiye.ORCID https://orcid.org/0000-0002-6223-5329
Erden BanogluDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara 06560, Türkiye.ORCID https://orcid.org/0000-0003-4737-1733
Onur CizmeciogluDepartment of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Türkiye.ORCID https://orcid.org/0000-0002-7608-6950

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isoxazole derivatives have emerged as promising scaffolds in anticancer drug discovery, yet their therapeutic potential remains to be fully harnessed. Here, we report on the synthesis and biological evaluation of two novel biotin-conjugated isoxazole derivatives (

Identifiers

PMID42395957
PMCPMC13325105

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.