ArticleClinical kidney journal2026
Renal lymphatic vessels correlate with disease activity and progression of IgA nephropathy: a retrospective cohort study.
Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rationale & objective: The progression of IgA nephropathy (IgAN) involves complement activation and inflammatory infiltration. Lymphatics is reported to connect tissue injury with immunoregulation effect. This study aimed to quantify renal lymphatic vessel (LV) density in a Chinese IgAN cohort, assess its correlation with complement and inflammation, and evaluate its long-term prognostic significance. Study design: Retrospective cohort study. Setting & participants: We enrolled 127 IgAN patients from Tongji Hospital (Wuhan, China) who were treatment-naïve at renal biopsy (no glucocorticoids or immunosuppressants) and had complete, valid follow-up data. Exposure: Renal LVs and inflammatory cells were assessed by histological staining; urinary galactose-deficient IgA1 (Gd-IgA1), complement components, and cytokines were measured by ELISA (Enzyme-Linked Immunosorbent Assay). Outcomes: Two independent primary endpoints were defined: (1) Serum creatinine (Scr) doubling and (2) end-stage renal disease (ESRD). Analytical approach: Cox proportional hazards regression. Result: In patients with IgAN, renal LVs density was significantly elevated compared to controls ( Limitations: Single-center retrospective design; sample size. Conclusion: Renal LVs density exhibits a significant correlation with urinary Gd-IgA1 levels, complement activation, inflammatory cell infiltration and renal lesions. Furthermore, a higher renal LVs density is closely associated with poorer renal outcomes.
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