ArticleWorld journal of nephrology2026
Pediatric cardiac surgery associated-acute kidney injury: Interleukin 18 as a new biomarker.
Article in World journal of nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCreatinine has been the widely accepted and used marker of cardiac surgery associated (CSA) acute kidney injury (AKI) in both adult and pediatric age groups, the diagnosis of which may take hours to days, leading to delayed recognition of renal dysfunction, and this may be partly responsible for the limited progress in preventing and treating postoperative AKI. This underscores the need for more sensitive markers of AKI.
aimTo assess the detection of AKI by interleukin 18 (IL-18) in contrast to creatinine among post-operative CSA children in Nigeria.
methodsPlasma samples were collected from forty consecutive children aged less than 15 years who had open heart surgery for treatment of congenital heart disease at six different time points (0-, 4-, 8-, 12-, 24-, 48 hours) and were assayed for IL-18 and creatinine using enzyme linked immuno-sorbent assay method and automated Jaffe kinetic method respectively.
resultsThe average plasma IL-18 concentrations at six different time points were 12.83 ng/L, 19.09 ng/L, 22.15 ng/L, 20.00 ng/L, 18.11 ng/L and 16.36 ng/L correspondingly with the greatest value at 8 hours. Receiver operating characteristic curve showed that IL-18 portend CSA-AKI with a specificity of 88% and a sensitivity of 100% at a limit point of 22 ng/L and had an area under the curve of 0.926.
conclusionIL-18 had a better specificity and sensitivity in the detection of CSA-AKI in pediatric age group than creatinine from the findings in this study.
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