ArticleWorld journal of nephrology2026
Comparison of infectious complications following early versus late pulse steroid therapy in renal transplant recipients.
Article in World journal of nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRenal transplant recipients are at increased risk of infections due to immunosuppression. Pulse steroid therapy, used to treat acute rejection, may further heighten this risk. However, the impact of the timing of pulse steroid therapy on infectious complications remains unclear.
aimTo compare infectious complications following early
methodsThis study included adult renal transplant recipients who received pulse steroid therapy either within 90 days (early) or after 90 days (late) post-transplantation between January 2016 and December 2020. Patients receiving both early and late pulse therapy were excluded. Infectious complications requiring hospitalization were recorded from the first pulse steroid dose until death or December 31, 2021. Infection burden was expressed as episodes per 100 patient-years, and incidence rate ratios (IRRs) with 95% confidence intervals (CI) were calculated.
resultsA total of 128 patients were included (early:
conclusionLate pulse steroid therapy in renal transplant recipients is associated with a significantly higher burden of infectious complications and mortality compared with early therapy. These findings highlight the need for enhanced surveillance and tailored infection prevention strategies following late intensification of immunosuppression.
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