SynthesisFrontiers in nutrition2026
Prognostic nutritional indices and long-term survival after endoscopic submucosal dissection for early gastric cancer in elderly patients: a systematic review and meta-analysis.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Nutritional risk and host vulnerability may influence long-term outcomes in elderly patients with early gastric cancer (EGC) undergoing endoscopic submucosal dissection (ESD). The prognostic nutritional index (PNI) and geriatric nutritional risk index (GNRI) are simple nutritional and prognostic indices, but their prognostic value in this population has not been systematically evaluated. Methods: We conducted a systematic review and meta-analysis of studies assessing the association between PNI or GNRI and long-term survival in elderly patients (≥ 65 years) treated with ESD for EGC. PubMed, Embase, and Web of Science were searched up to December 28, 2025. Hazard ratios (HRs) or comparable multivariable estimates with 95% confidence intervals (CIs) were synthesized using fixed- or random-effects models. Subgroup and sensitivity analyses were conducted to assess consistency and heterogeneity. Results: Conclusion: Lower PNI and GNRI were associated with poorer survival outcomes in elderly patients with EGC treated by ESD. These findings highlight the potential clinical relevance of nutritional risk assessment and may help inform risk stratification, but further prospective studies are needed to validate their clinical utility and assess whether targeted interventions can modify outcomes. Systematic review registration: identifier: CRD420251270408.
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