ArticleFrontiers in pediatrics2026
Association between glucolipid metabolic indicators and the risk of suspected precocious puberty in children living with obesity: a retrospective cohort study.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the association between glucolipid metabolic indicators and suspected precocious puberty (PP) in children living with obesity. Methods: This retrospective observational study initially included 100 children with obesity (BMI ≥95th percentile) hospitalized between March 2022 and June 2025. Sexual development was assessed by Tanner staging. Children were categorized into suspected PP ( Results: The suspected PP group had significantly higher FPG, FINS, HOMA-IR, TG, TC, LDL-C, uric acid, sex hormones, and bone age advancement (1.88 ± 0.64 vs. 0.86 ± 0.48 years), and lower HDL-C (all Conclusion: Suspected precocious puberty in children living with obesity is closely associated with insulin resistance, elevated triglycerides, and hyperuricemia, whereas higher HDL-C is protective. These findings highlight the importance of early metabolic monitoring in this inpatient population, with the caveat that the cohort represents a selected hospitalized sample.
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