Evidence map›Paper›PMID 42395607›Full record

ArticleFrontiers in pediatrics2026

The levels of vascular endothelial cells and endothelium-dependent vasomotor cytokines in children with essential hypertension: a case-control study.

Jingjing Ma, Yaxi Cui, Yao Lin, Yanyan Liu, Yang Liu, Lin Shi

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Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jingjing MaDepartment of Cardiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China.
Yaxi CuiDepartment of Cardiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China.
Yao LinDepartment of Cardiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China.
Yanyan LiuDepartment of Cardiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China.
Yang LiuDepartment of Cardiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China.
Lin ShiDepartment of Cardiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Circulating endothelial cells (CECs), endothelial progenitor cells (EPCs) and endothelium-dependent vasomotor cytokines are important in maintaining endothelial function stability. However, these alterations have not been documented in childhood essential hypertension. This study aim to investigate the levels of CECs, EPCs and endothelium-dependent vasomotor cytokines in children with essential hypertension. Methods: A total of 101 children with essential hypertension and 30 healthy children were recruited as hypertension (HTN) group and control group, respectively. Peripheral CEC and EPC counts, nitrite (NO Results: The level of CECs in the HTN group was significantly higher than that in the control group ( Conclusion: CECs, EPCs and endothelium-dependent vasomotor cytokines were altered in pediatric essential hypertension, suggesting that endothelial dysfunction may play a role in its pathogenesis.

Indexed as

childendothelial cellsendothelial functionendothelium-dependent vasomotor cytokinesessential hypertension

Identifiers

PMID42395607
PMCPMC13323709

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.