Evidence map›Paper›PMID 42395577›Full record

ArticlebioRxiv : the preprint server for biology2026

When does additional information improve accuracy of RNA secondary structure prediction?

Logan Rose, Luis Sanchez Giraldo, Duc Nguyen, Matthew Wheeler, David Murrugarra

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Logan RoseDepartment of Mathematics, University of Kentucky, Lexington, KY 40506, USA.
Luis Sanchez GiraldoDepartment of Electrical and Computer Engineering, University of Kentucky, Lexington, KY 40506, USA.
Duc NguyenDepartment of Mathematics, University of Tennessee, Knoxville, TN 37996, USA.ORCID 0000-0003-2215-0328
Matthew WheelerDepartment of Medicine, University of Florida, Gainesville, FL 32610, USA.
David MurrugarraDepartment of Mathematics, University of Kentucky, Lexington, KY 40506, USA.ORCID 0000-0001-9710-5025

Funding

Multiscale modeling of the role of heme during invasive pulmonary aspergillosisR01AI135128 · NIAID · UNIVERSITY OF FLORIDA · PI REINHARD LAUBENBACHER, Borna Mehrad · 2018 to 2026
$4.9M
NIAID NIH HHS R01 AI135128
6 · The paper itself

Abstract

The secondary structure of an RNA sequence plays an important role in determining its function, and accurate prediction of the structure is still a major goal in computational biology. Improvements in the prediction accuracy of the secondary structure can be achieved via auxiliary information. In this paper, we study features based on suboptimal formations competing with the minimum-free energy formation and investigate their role in determining the improvement of accuracy via auxiliary information, which we call directability. Here, we introduce a similarity measure among competing substructures called profiles. Then, we present an

Identifiers

PMID42395577
PMCPMC13320844

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.