ArticlebioRxiv : the preprint server for biology2026
Normative brain-state trajectories reveal deviation from healthy aging in AD.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
introductionDistinguishing healthy brain aging from early neurodegenerative disruption remains a major challenge in Alzheimer's disease.
methodsUsing resting-state fMRI from the Alzheimer's Disease Neuroimaging Initiative (357 participants; cognitively normal, mild cognitive impairment, Alzheimer's disease), we trained a Hidden Markov Model exclusively on cognitively normal adults to define latent connectivity states. A generalized additive model estimated an age-adjusted reference trajectory of transition entropy, and subject-specific deviations from this trajectory were quantified.
resultsMild cognitive impairment and Alzheimer's disease showed progressively greater deviation from the normative reference, with the strongest disruption in Alzheimer's disease. A single absolute-deviation score retained much of the predictive information contained in higher-dimensional dynamic features. DISCUSSION: These findings suggest Alzheimer's disease is associated with measurable departure from healthy dynamic brain aging, providing an interpretable framework for future longitudinal and clinically validated studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.