Evidence map›Paper›PMID 42395560›Full record

ArticlebioRxiv : the preprint server for biology2026

Fine mapping of PTSD GWAS reveals a role for amygdala

O Ponomareva, L T Seabrook, M Maya-Martinez, C Klengel, V Balakundi, S Kini, E Catt, J Zion, R Shah, P Martinez and 15 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

O PonomarevaMcLean Hospital, Belmont MA.ORCID 0000-0003-2409-3275
L T SeabrookMcLean Hospital, Belmont MA.
M Maya-MartinezMcLean Hospital, Belmont MA.
C KlengelMcLean Hospital, Belmont MA.
V BalakundiMcLean Hospital, Belmont MA.
S KiniNortheastern University, Boston MA.
E CattNortheastern University, Boston MA.
J ZionNortheastern University, Boston MA.
R ShahUniversity of Toledo, Toledo OH.
P MartinezMcLean Hospital, Belmont MA.
E HernandezNortheastern University, Boston MA.
Z BeattyMcLean Hospital, Belmont MA.
M S MilletMcLean Hospital, Belmont MA.
Q Flanagan-BurtMcLean Hospital, Belmont MA.
A A LussierMcLean Hospital, Belmont MA.
C M NievergeltUniversity of California San Diego, La Jolla, CA.
A X MaihoferUniversity of California San Diego, La Jolla, CA.
K KoenenHarvard T.H. Chan School of Public Health, Boston MA.
PTSD Working Group of Psychiatric Genomics Consortium
PsychENCODE PTSD BrainOmics Project
J E KleinmanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore MD.
J SuhMcLean Hospital, Belmont MA.
W A CarlezonMcLean Hospital, Belmont MA.
N P DaskalakisMcLean Hospital, Belmont MA.
K J ResslerMcLean Hospital, Belmont MA.

Funding

Roles of nuleus accumbens CREB and Kappa function in depressionR01MH063266 · NIMH · MC LEAN HOSPITAL (BELMONT, MA) · PI CARLEZON, WILLIAM A. · 2001 to 2025
$9.1M
Psychiatric Genomics Consortium for PTSDR01MH106595 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARESTAN C KOENEN, Caroline M Nievergelt · 2016 to 2026
$8.4M
Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala PathwaysR01MH108665 · NIMH · MCLEAN HOSPITAL · PI BOLSHAKOV, VADIM, RESSLER, KERRY J. · 2016 to 2025
$7.5M
2/3 Understanding PTSD through Postmortem Targeted Brain Multi-omicsR01MH117291 · NIMH · LIEBER INSTITUTE, INC. · PI Joel Edward Kleinman · 2018 to 2026
$5.2M
Site 3/3, Understanding PTSD through Postmortem Targeted Brain MultiomicsR01MH117292 · NIMH · MCLEAN HOSPITAL · PI Nikolaos Daskalakis, KERRY J. RESSLER · 2018 to 2026
$5.0M
Next steps for PTSD genomics: from loci to functionR01MH133268 · NIMH · MCLEAN HOSPITAL · PI Nikolaos Daskalakis, Caroline M Nievergelt · 2024 to 2026
$2.5M
Insula-amygdala circuits in alcohol abuseR01AA030585 · NIAAA · MCLEAN HOSPITAL · PI Junghyup Suh · 2023 to 2026
$2.1M
Understanding Foxp2-Mediated Molecular Signaling in Fear LearningK08MH130802 · NIMH · MCLEAN HOSPITAL · PI Olga Y Ponomareva · 2023 to 2026
$777k
NIAAA NIH HHS R01 AA030585NIMH NIH HHS K08 MH130802NIMH NIH HHS R01 MH063266NIMH NIH HHS R01 MH106595NIMH NIH HHS R01 MH108665NIMH NIH HHS R01 MH117291NIMH NIH HHS R01 MH117292NIMH NIH HHS R01 MH133268
6 · The paper itself

Abstract

Post-traumatic Stress Disorder (PTSD) is a debilitating psychiatric condition caused by severe trauma exposure and characterized by ongoing dysregulation of fear processing, hyperarousal, and amygdala activation, but with limited effective treatments. Recent large-scale genome-wide association studies (GWAS) of PTSD have identified the transcription factor FOXP2 as a highly-significant, top putative risk gene. Both fine-mapping of the PTSD GWAS with amygdala-specific expression quantitative trait loci (eQTL) data, and transcriptome-wide association analyses, show that altered expression of

Identifiers

PMID42395560
PMCPMC13320800

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.