ArticlebioRxiv : the preprint server for biology2026
A corticostriatal circuit updates subjective beliefs about latent task states.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
8 authors.
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Abstract
Beliefs about states of the world profoundly impact decision-making and learning, but little is known about how neural circuits represent and update beliefs. We performed projection-specific recordings and perturbations from neurons in the orbitofrontal cortex (OFC) projecting to the intermediate or rostral caudate putamen (CPi/CPr) in rats performing a task with hidden reward states. Stimulating OFC→CPi neurons biased rats' beliefs towards high reward states. Recordings from optogenetically-tagged OFC→CPi neurons showed that they encoded categorical evidence for high reward states, shaped by a saturating non-linearity in neural responses. Downstream neurons could, in principle, decode the full belief distribution over reward states as rats deliberated about decisions. Finally, projection-specific perturbations disrupted encoding of hidden states within OFC. These findings reveal the circuit implementation of a core cognitive computation, updating subjective beliefs about abstract latent states of the environment.
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