Evidence map›Paper›PMID 42395540›Full record

ArticlebioRxiv : the preprint server for biology2026

HPL-2/HP1 and MET-2/SETDB1 bind distinct co-factors that promote heterochromatic foci, gene repression and organogenesis independently of H3K9 methylation.

Colin E Delaney, Lisa Fol, Jia Emil You, Stefan B Gruenewald, Eugenio Ferrario, Susan M Gasser, Martin M Moeckel, Lukas Stelzl, Jan Padeken, Susan E Mango

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Colin E DelaneyUniversity of Basel Biozentrum, Basel, Switzerland.ORCID 0000-0001-6880-6973
Lisa FolInstitute for Molecular Biology (IMB), Mainz, Germany.
Jia Emil YouUniversity of Basel Biozentrum, Basel, Switzerland.ORCID 0009-0005-1151-8125
Stefan B GruenewaldInstitute of Molecular Physiology, Johannes Gutenberg University Mainz, Mainz, Germany.
Eugenio FerrarioInstitute for Molecular Biology (IMB), Mainz, Germany.
Susan M GasserFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland.ORCID 0000-0003-3610-9123
Martin M MoeckelInstitute for Molecular Biology (IMB), Mainz, Germany.
Lukas StelzlInstitute for Molecular Biology (IMB), Mainz, Germany.
Jan PadekenInstitute for Molecular Biology (IMB), Mainz, Germany.ORCID 0000-0001-6538-0946
Susan E MangoUniversity of Basel Biozentrum, Basel, Switzerland.ORCID 0000-0002-2146-3237

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

In differentiated cells, genome segregation into heterochromatin and euchromatin is mediated by modified histones, which recruit so-called reader proteins. Surprisingly, many histone modifiers remain functional in the absence of catalytic activity, but the underlying mechanism remains unclear. To explore this puzzle, we examined the relationship between

Identifiers

PMID42395540
PMCPMC13321349

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.