Evidence map›Paper›PMID 42395534›Full record

ArticlebioRxiv : the preprint server for biology2026

Novel

Christian Mei, Jillian Ness, Katherine Nakai, Zeba Wunderlich

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christian MeiDepartment of Biology, Boston University, Boston, MA USA 02215.
Jillian NessDepartment of Biology, Boston University, Boston, MA USA 02215.
Katherine NakaiDepartment of Biology, Boston University, Boston, MA USA 02215.
Zeba WunderlichDepartment of Biology, Boston University, Boston, MA USA 02215.ORCID 0000-0003-4491-5715

Funding

Mechanisms of shadow enhancer robustness during developmentR01HD095246 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI Zeba B Wunderlich · 2018 to 2026
$2.7M
NICHD NIH HHS R01 HD095246
6 · The paper itself

Abstract

Developmental processes depend on carefully coordinated gene expression. Expression is modulated by the binding of transcription factors (TFs) to cis-regulatory elements (CREs), like enhancers and promoters. Many computational and experimental approaches have been developed to find CREs, particularly enhancers, in the genome, each with strengths and caveats. Given the increasing availability of ATAC-seq data and methods to find TF binding therein, we hypothesized that we could use TF footprinting tools to find clusters of TF binding events within accessible chromatin that may act as CREs. Using

Identifiers

PMID42395534
PMCPMC13320873

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.