Evidence map›Paper›PMID 42395510›Full record

ArticlebioRxiv : the preprint server for biology2026

Cerebrovascular Imaging-to-Graph Reconstruction for Individualized Digital Twin Brains.

Chen Xie, Beini Hu, Abdulmalik M Alakeel, Candace C Fleischer, Andrei G Fedorov

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chen XieWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.ORCID 0000-0003-1629-5766
Beini HuWalter H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30322, USA.
Abdulmalik M AlakeelWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Candace C FleischerWalter H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30322, USA.
Andrei G FedorovWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

Funding

Synergistic Advancements in MR Thermometry and Predictive Thermal Modeling Towards Improved Characterization of Human Brain TemperatureR01NS138044 · NINDS · EMORY UNIVERSITY · PI FLEISCHER, CANDACE C. · 2024 to 2025
$1.2M
NINDS NIH HHS R01 NS138044
6 · The paper itself

Abstract

The development of digital twins in medicine, i.e., virtual replicas of human organs, offers a promising path toward precision medicine by enabling interpretable, mechanistic, and actionable insights. In the brain, cerebrovascular twins support individualized modeling of hemodynamics and bio-transport, with broad applications. A major bottleneck, however, is the lack of robust methods to transform

Indexed as

Brain biophysical simulationCerebrovascular graph reconstructionDigital twin brain

Identifiers

PMID42395510
PMCPMC13320791

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.