Evidence map›Paper›PMID 42395492›Full record

ArticlebioRxiv : the preprint server for biology2026

An Integrated muti-omics cell atlas of the human trabecular meshwork and ciliary body.

Jinjing Jian, Xuan Bao, Jun Wang, Ye Zheng, Jin Li, Jianming Shao, Tingting Yang, Ismail Yaman, Jean Li, Han Chen and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Jinjing JianDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0009-0009-3912-1655
Xuan BaoBrunson Center for Translational Vision Research, Gavin Herbert Eye Institute, Department of Ophthalmology and Visual Sciences, University of California, Irvine, School of Medicine, Irvine, CA, USA.ORCID 0009-0009-4842-2724
Jun WangDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Ye ZhengBrunson Center for Translational Vision Research, Gavin Herbert Eye Institute, Department of Ophthalmology and Visual Sciences, University of California, Irvine, School of Medicine, Irvine, CA, USA.
Jin LiBrunson Center for Translational Vision Research, Gavin Herbert Eye Institute, Department of Ophthalmology and Visual Sciences, University of California, Irvine, School of Medicine, Irvine, CA, USA.ORCID 0000-0001-8975-6776
Jianming ShaoDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.ORCID 0009-0001-3782-4383
Tingting YangDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Ismail YamanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Jean LiDepartment of Biomedical Engineering, Department of Physiology & Biophysics. University of California, Irvine, Irvine, CA, USA.
Han ChenRory Meyers College of Nursing, New York University, New York, NY, USA.
Nicholas TolmanDepartment of Ophthalmology, Vagelos college of Physicians and Surgeons Columbia University Irving Medical Center, New York, NY, USA.
Richard H ScheuermannDivision of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Jie J ZhengStein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine, The Molecular Biology Institute at the University of California, Los Angeles, CA, USA.
Carl SheridanDepartment of Eye and Vision Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
Yutao LiuDepartment of Ophthalmology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-2870-4504
Yiqin DuDepartment of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Revathi BalasubramanianDepartment of Ophthalmology, Vagelos college of Physicians and Surgeons Columbia University Irving Medical Center, New York, NY, USA.
Gulab S ZodeBrunson Center for Translational Vision Research, Gavin Herbert Eye Institute, Department of Ophthalmology and Visual Sciences, University of California, Irvine, School of Medicine, Irvine, CA, USA.
Simon Wm JohnDepartment of Ophthalmology, Vagelos college of Physicians and Surgeons Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-4319-0356
J Timothy StoutDepartment of Ophthalmology, Baylor College of Medicine, Houston, TX, USA.
W Daniel StamerDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
Yumei LiBrunson Center for Translational Vision Research, Gavin Herbert Eye Institute, Department of Ophthalmology and Visual Sciences, University of California, Irvine, School of Medicine, Irvine, CA, USA.
Rui ChenBrunson Center for Translational Vision Research, Gavin Herbert Eye Institute, Department of Ophthalmology and Visual Sciences, University of California, Irvine, School of Medicine, Irvine, CA, USA.ORCID 0000-0002-4387-9735

Funding

eNOS-Dependent Mechanoregulation of Intraocular PressureR01EY022359 · NEI · DUKE UNIVERSITY · PI STAMER, W DANIEL · 2012 to 2025
$5.6M
Mechanisms of Trabecular Meshwork Regeneration by Stem CellsR01EY025643 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI Yiqin Du · 2015 to 2026
$4.2M
Caveolae-Based Mechanosensors for Conventional Outflow RegulationR01EY028608 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MICHAEL H ELLIOTT, W Daniel Stamer · 2018 to 2026
$3.8M
NEI UCI Center Core Grant for Vision ResearchP30EY034070 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vladimir Jivkov Kefalov · 2022 to 2026
$3.7M
Models, mechanisms and treatment of LMX1B-induced glaucomaR01EY032507 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JOHN, SIMON W · 2021 to 2024
$2.3M
High Throughput Genomic Sequencer at BCM Core FacilityS10OD023469 · OD · BAYLOR COLLEGE OF MEDICINE · PI CHEN, RUI · 2017 to 2017
$600k
NEI NIH HHS P30 EY034070NEI NIH HHS R01 EY022359NEI NIH HHS R01 EY025643NEI NIH HHS R01 EY028608NEI NIH HHS R01 EY032507NIH HHS S10 OD023469
6 · The paper itself

Abstract

The trabecular meshwork (TM) and ciliary body (CB) regulate aqueous humor dynamics and intraocular pressure (IOP), and TM/Schlemm's canal (SC) dysfunction underlies glaucoma. Here, we present a spatially resolved multi-omics atlas of human TM and CB, integrating snRNA-seq, scRNA-seq, and snATAC-seq from over one million cells and nuclei across 112 donors with Xenium spatial transcriptomics. We identified 9 major cell classes and 21 cell types, revealing heterogeneity, including undercharacterized fibroblast and epithelial subpopulations. Spatial mapping supported TM fibroblast zonation and CB epithelial organization. Regulatory analyses identified cell type-specific programs, including OTX/PAX networks in CB epithelium and SMAD3/TGF-β signaling in fibroblasts. Integration with glaucoma loci showed enrichment of non-coding variants in regulatory elements associated with POAG and PACG. Age- and ancestry-associated remodeling revealed divergent fibroblast aging with increased

Identifiers

PMID42395492
PMCPMC13320969

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.