Evidence map›Paper›PMID 42395469›Full record

ArticlebioRxiv : the preprint server for biology2026

Bacteriophage Heteroresistance as a Cause of Treatment Failure in Urinary Tract Infections.

Serena Singh-Ward, Alysha S Ismail, Teresa Gil-Gil, Brandon A Berryhill, Michael H Woodworth, Hope E Shanks, Bruce R Levin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Serena Singh-WardDepartment of Biology, Emory University, Atlanta, Georgia, USA, 30322.
Alysha S IsmailDepartment of Biology, Emory University, Atlanta, Georgia, USA, 30322.
Teresa Gil-GilDepartment of Biology, Emory University, Atlanta, Georgia, USA, 30322.
Brandon A BerryhillDepartment of Biology, Emory University, Atlanta, Georgia, USA, 30322.
Michael H WoodworthDepartment of Biology, Emory University, Atlanta, Georgia, USA, 30322.
Hope E ShanksDepartment of Biology, Emory University, Atlanta, Georgia, USA, 30322.
Bruce R LevinDepartment of Biology, Emory University, Atlanta, Georgia, USA, 30322.

Funding

Single Cell Analysis Core (Core C)U19AI158080 · NIAID · EMORY UNIVERSITY · PI LEVIN, BRUCE RICHARD, WEISS, DAVID S · 2021 to 2025
$10.9M
Theoretical and Experimental Studies of the Population and Evolutionary Dynamics of Bacteria and Bacteriophage.R35GM136407 · NIGMS · EMORY UNIVERSITY · PI LEVIN, BRUCE RICHARD · 2020 to 2024
$2.0M
NIAID NIH HHS U19 AI158080NIGMS NIH HHS R35 GM136407
6 · The paper itself

Abstract

With the rise of antimicrobial resistance, urinary tract infections (UTIs) have become increasingly more difficult to treat, prompting renewed interest in bacteriophage (phage) therapy as an alternative or adjunct to antibiotics. UTIs are an attractive target for phage therapy because they generate a high density of actively replicating bacteria that supports phage propagation, and because the urinary tract is readily accessible for administration and monitoring. Yet studies of phage therapy for UTIs report mixed outcomes, including failures to meet clinical and microbiological endpoints. Here we follow the population dynamics of a clinical

Indexed as

Antibiotic ResistanceEvolutionHeteroresistancePhage TherapyUrinary Tract Infections

Identifiers

PMID42395469
PMCPMC13321061

What OpenQuestion holds

Textmetadata
LicenceCC0
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.