Evidence map›Paper›PMID 42395463›Full record

ArticlebioRxiv : the preprint server for biology2026

Scaling of Neuronal Growth and Excitability Through Separable mTORC1 and mTORC2 Pathways.

Asan F Abdulkareem, Noah H Elste, Rain Younger, Mackenzi L Prina, Evan Dennis, Jessica Urbanczyk, Mohsen Bayat, Hassaan A Malik, Shahriar A Tafti, Hunter S Holoubek and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Asan F AbdulkareemDepartment of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Noah H ElsteDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington VT.
Rain YoungerDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington VT.
Mackenzi L PrinaDepartment of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Evan DennisDepartment of Neurosurgery, Massachusetts General Hospital & Harvard Medical School, Boston, MA.
Jessica UrbanczykFralin Biomedical Research Institute, Virginia Tech, Roanoke, VA.
Mohsen BayatDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington VT.
Hassaan A MalikDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington VT.
Shahriar A TaftiDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington VT.
Hunter S HoloubekDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington VT.
Dylan MarchandDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington VT.
Karen E BeenkenIDEA National Resource for Quantitative Proteomics, University of Arkansas for Medical Sciences, Little Rock, AR.
Dennis W ProvinceIDEA National Resource for Quantitative Proteomics, University of Arkansas for Medical Sciences, Little Rock, AR.
Kristopher T KahleDepartment of Neurosurgery, Massachusetts General Hospital & Harvard Medical School, Boston, MA.
Matthew C WestonFralin Biomedical Research Institute, Virginia Tech, Roanoke, VA.
Jeremy M BarryDepartment of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington VT.
Bryan W LuikartDepartment of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL.

Funding

Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
The Impact of PTEN Signaling on Neuronal Form and FunctionR01MH097949 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRYAN W LUIKART · 2012 to 2026
$7.4M
Human Genetics and Molecular Mechanisms of Congenital HydrocephalusR01NS111029 · NINDS · YALE UNIVERSITY · PI DENIZ, ENGIN, JIN, SHENG CHIH · 2020 to 2024
$2.5M
Modulation of Choroid Plexus Immuno-secretory Function to Restore Cerebrospinal Fluid Homeostasis in HydrocephalusR01NS109358 · NINDS · YALE UNIVERSITY · PI Kristopher T. Kahle · 2018 to 2026
$2.4M
Synaptic changes and hypersynchronous network activity in mTORopathiesR01NS110945 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI WESTON, MATTHEW C · 2019 to 2023
$1.7M
Training Program in Cell, Molecular, and Developmental BiologyT32GM146611 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Susan L Bellis · 2024 to 2026
$1.4M
Cortical Networks Encoding Higher-Order Memories that Elicit FearR01MH134787 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Jeremy Michael Barry, Travis Todd · 2024 to 2026
$1.1M
Neocortical and Hippocampal Circuit Dysfunction in the KCNT1 Model of EpilepsyR21NS133670 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Jeremy Michael Barry · 2025 to 2026
$440k
NIGMS NIH HHS R24 GM137786NIGMS NIH HHS T32 GM146611NIMH NIH HHS R01 MH097949NIMH NIH HHS R01 MH134787NINDS NIH HHS R01 NS109358NINDS NIH HHS R01 NS110945NINDS NIH HHS R01 NS111029NINDS NIH HHS R21 NS133670
6 · The paper itself

Abstract

As neurons grow, they must regulate intrinsic excitability to maintain an appropriate level of spiking based on synaptic inputs. Using gene knockouts, phosphoproteomics, and electrophysiology we show PTEN regulates neuronal growth and intrinsic excitability through separable downstream mechanisms.

Identifiers

PMID42395463
PMCPMC13320910

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.