Evidence map›Paper›PMID 42395428›Full record

ArticlebioRxiv : the preprint server for biology2026

ESCRT-0 regulates AMPA receptor currents and Ca

Mahsa Pourhamzeh, Lara Dozier, Amanda Wilpitz, Yixing Du, Daniel B McClatchy, Mariel K B Micael, Joshua E Mayfield, Stephen K Gilmore-Hall, Josephina E Ronson, Katrin Soldau and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Mahsa PourhamzehDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-6712-7220
Lara DozierDepartment of Neurobiology, University of California at San Diego, La Jolla, CA 92093, USA.
Amanda WilpitzDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Yixing DuDepartment of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA.
Daniel B McClatchyDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-0288-5645
Mariel K B MicaelDepartment of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA.
Joshua E MayfieldDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Stephen K Gilmore-HallDepartment of Neurobiology, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5919-2033
Josephina E RonsonDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Katrin SoldauDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Donald P PizzoDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Brent AulstonDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Erin E SullivanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Timothy F ShayDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Jin WangDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Subhojit RoyDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.
Viviana GradinaruDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Justin H TrotterDepartment of Neurobiology, University of California at San Diego, La Jolla, CA 92093, USA.
Kim DoreDepartment of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA.
John R YatesDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-5267-1672
Gentry N PatrickDepartment of Neurobiology, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-6405-4401
Christina J SigurdsonDepartment of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-1770-0965

Funding

UC San Diego FIRST ProgramU54CA272220 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Deborah L Wingard · 2022 to 2026
$21.2M
Mechanisms of Prion Aggregation and Species BarriersR01NS069566 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ESKO, JEFFREY D, RAVITS, JOHN · 2011 to 2025
$5.7M
Mechanisms of Prion SpreadR01NS076896 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIGURDSON, CHRISTINA · 2012 to 2021
$3.4M
Mechanisms of Prion Spread and Neuronal ToxicityR37NS076896 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Christina Sigurdson · 2023 to 2026
$2.6M
Molecular basis of prion protein-induced neurodegenerationRF1NS121992 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIGURDSON, CHRISTINA · 2021 to 2023
$1.7M
Increasing synaptic PSD-95, a neuroprotection approach against Alzheimer's diseaseRF1AG067049 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DORE, KIM BOHEMIE · 2021 to 2021
$1.4M
Increasing synaptic PSD-95, a neuroprotection approach against Alzheimer's diseaseR01AG067049 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DORE, KIM BOHEMIE · 2024 to 2025
$978k
Molecular basis of prion protein-induced neurodegenerationR01NS121992 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIGURDSON, CHRISTINA · 2024 to 2025
$963k
Determining pathogenic PrPC-induced signaling pathways in human iPSC-induced neuronsR21NS135426 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIGURDSON, CHRISTINA · 2023 to 2023
$435k
NCI NIH HHS U54 CA272220NIA NIH HHS R01 AG067049NIA NIH HHS RF1 AG067049NINDS NIH HHS R01 NS069566NINDS NIH HHS R01 NS076896NINDS NIH HHS R01 NS121992NINDS NIH HHS R21 NS135426NINDS NIH HHS R37 NS076896NINDS NIH HHS RF1 NS121992
6 · The paper itself

Abstract

Membrane protein trafficking is essential for synaptic growth, maintenance, function, and plasticity, and involves the regulated exocytosis and endocytosis of proteins to and from the pre- and post-synaptic membranes. Defects in the clearance of membrane proteins can lead to the accumulation of ubiquitinated membrane proteins and contribute to neurodegenerative disease. The ESCRT (endosomal sorting complexes required for transport) machinery binds and sorts ubiquitinated membrane proteins into lysosomes for degradation, yet the presence and function of ESCRTs in sorting ubiquitinated AMPA and other receptors at the post-synapse remain unclear. Here we show that the ubiquitin-binding ESCRT-0 protein, Hrs, localizes to both pre- and post-synapses, and levels are modulated by neuronal activity, increasing and decreasing with higher and lower neuronal activity, respectively. Phosphoproteomic profiling of Hrs-depleted post-synaptic membranes revealed a role for Hrs in glutamatergic synaptic transmission, including long-term potentiation. In addition, Hrs-depleted neurons showed faster AMPAR current kinetics and reduced amplitude in whole-cell patch-clamp recordings. Genetic deletion of neuronal

Identifiers

PMID42395428
PMCPMC13320757

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.