Evidence map›Paper›PMID 42395427›Full record

ArticlebioRxiv : the preprint server for biology2026

Primary-Level Meta-Analysis of Diversity Outbred Mice Identifies a Fasting Plasma Trimethylamine N-Oxide (TMAO) Locus Modified by Sex and Diet.

Kristen J Sutton, Levi W Evans, Erik R Gertz, Dawson Budke, Nazmul Huda, Phoebe Yam, Myungsuk Kim, Jennifer Rutkowsky, Diana Shih, Jaana Hartiala and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kristen J SuttonDepartment of Nutrition, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-3704-3560
Levi W EvansUSDA-ARS Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA.
Erik R GertzUSDA-ARS Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA.
Dawson BudkeDepartment of Nutrition, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
Nazmul HudaDepartment of Nutrition, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0003-2775-4470
Phoebe YamUSDA-ARS Western Human Nutrition Research Center, 430 West Health Sciences Drive, Davis, CA 95616, USA.
Myungsuk KimDepartment of Nutrition, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.
Jennifer RutkowskyDepartment of Nutrition, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-0046-7693
Diana ShihDivision of Cardiology, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Jaana HartialaDivision of Cardiology, Department of Medicine, University of California, Los Angeles, CA 90095, USA.
Daniel PompDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Aldons J LusisDepartments of Medicine, Human Genetics, and Microbiology, Immunology, & Molecular Genetics, David Geffen School of Medicine of UCLA, Los Angeles, CA 90095, USA.
Hooman AllayeeDivision of Cardiology, Department of Medicine, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-2384-5239
Brian J BennettDepartment of Nutrition, University of California Davis, One Shields Avenue, Davis, CA 95616, USA.ORCID 0000-0002-0766-3195

Funding

Biological Mechanisms through which TMAO Promotes AtherosclerosisR01HL148110 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLAYEE, HOOMAN, SHIH, DIANA MOUHAN · 2020 to 2023
$2.5M
Genetic Predisposition to Myocardial Infarction in Patients with Coronary Artery DiseaseR01HL168493 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Hooman Allayee · 2024 to 2026
$2.2M
Genetic and Gut Microbial Regulation of Indole-3 Propionate in Metabolic DiseaseR01DK143650 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Hooman Allayee, Aldons Jake Lusis · 2026 to 2026
$779k
NHLBI NIH HHS R01 HL148110NHLBI NIH HHS R01 HL168493NIDDK NIH HHS R01 DK143650
6 · The paper itself

Abstract

Trimethylamine n-oxide (TMAO) is a plasma metabolite linked to adverse cardiometabolic health with complex regulation involving diet, sex, and host genetics. We explored the role of these factors in the genetic regulation of TMAO by performing a primary-level meta-analysis in 1,482 female and male Diversity Outbred (DO) mice from five distinct studies conducted in various regions of the United States. We identified a quantitative trait locus (QTL) associated with TMAO concentration at ~86 megabase pairs on mouse chromosome 12 with a highly significant LOD score of 67.67. Alleles at the chromosome 12 QTL inherited from the Cast/EiJ (CAST) and PWK/PhJ (PWK) mouse strains primarily drove the association with reduced TMAO concentrations. The chromosome 12 QTL remained significant in sex-stratified analyses and the mode of inheritance appeared additive; furthermore, the QTL was regulated by sex-by-genotype and sex-by-diet interactions. Using a CAST/EiJ X C57BL/6J F2 cross, positional candidates were prioritized by eQTL analysis. Further analysis in a study utilizing the eight DO founding strains identified that

Identifiers

PMID42395427
PMCPMC13321081

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.