Evidence map›Paper›PMID 42395406›Full record

ArticlebioRxiv : the preprint server for biology2026

The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes.

Jory van Thiel, Noah L Dowell, Cara F Smith, Elda E Sanchez, Sean B Carroll

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jory van ThielHoward Hughes Medical Institute and Department of Biology, University of Maryland, College Park, 20742, United States of America.
Noah L DowellHoward Hughes Medical Institute and Department of Biology, University of Maryland, College Park, 20742, United States of America.
Cara F SmithCentre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Elda E SanchezNational Natural Toxins Research Center, Texas A&M University-Kingsville, Kingsville, 78363, United States of America.
Sean B CarrollHoward Hughes Medical Institute and Department of Biology, University of Maryland, College Park, 20742, United States of America.ORCID 0000-0002-7839-5458

Funding

Viper Resource Grant at Texas A&M University-KingsvilleP40OD010960 · OD · TEXAS A&M UNIVERSITY-KINGSVILLE · PI Elda E. Sanchez · 2012 to 2026
$9.2M
NIH HHS P40 OD010960
6 · The paper itself

Abstract

Evolutionary innovation is a key driver of the colonization of new environments and the adaptive radiations of major groups. Novel traits typically evolve through the modification of pre-existing characters but the genetic paths underlying their origin have been challenging to trace, and the general requirements for and relative order of different kinds of gene mutations have been difficult to assess. Here, we trace the genomic origins of four procoagulant venom toxins (factor X, factor V, group I phospholipase A

Indexed as

Biological Sciences: Evolutioncoagulationconvergent evolutionevolutionary noveltygene co-optionsnake venom

Identifiers

PMID42395406
PMCPMC13320979

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.