Evidence map›Paper›PMID 42395400›Full record

ArticlebioRxiv : the preprint server for biology2026

Chromatin topology control by a muscle-specific ribosomal protein.

Makoto Nakamura, Xiaoxin Chen, Shun Yao, Lynette Xin Chan, Ruan Hongmei, Alexis Boulinguiez, Nav Lally, Hao Wu, Kara Kodani, Kentaro Hirose and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Makoto NakamuraCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Xiaoxin ChenCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Shun YaoCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Lynette Xin ChanDepartment of Neurobiology, Stanford University, Stanford, CA, USA.
Ruan HongmeiCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Alexis BoulinguiezUMRS974 - Center of Research in Myology Bâtiment Babinski, 50-52 Boulevard Vincent Auriol, 75013 Paris.
Nav LallyCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Hao WuDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Kara KodaniCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Kentaro HiroseCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
James PirruccelloCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Alberto MalerbaComparative Biomedical Sciences; Royal Veterinary College; 4, Royal College Street; London, NW1 0TU; United Kingdom.
Yifan ChengDepartment of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Vasanth VedanthamCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Longzhi TanDepartment of Neurobiology, Stanford University, Stanford, CA, USA.
Jeffrey E OlginCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Di LangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.
Guo N HuangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, USA.

Funding

Molecular control of cardiac regenerative potentialR01HL138456 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Guo Huang · 2018 to 2026
$5.1M
Molecular Biophysics Training Program at StanfordT32GM136568 · NIGMS · STANFORD UNIVERSITY · PI Zev Bryant, KERWYN C. HUANG · 2021 to 2026
$3.7M
Cell Identity and Functional Diversity of Sinoatrial Node Pacemaker Cell Subpopulations in the Physiology and Pathology of Cardiac PacemakingR01HL173344 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Di Lang · 2025 to 2026
$1.1M
NHLBI NIH HHS R01 HL138456NHLBI NIH HHS R01 HL173344NIGMS NIH HHS T32 GM136568
6 · The paper itself

Abstract

Three-dimensional genome organization stabilizes cell-type-specific gene expression, yet the tissue-restricted factors that maintain chromatin insulation remain poorly understood. Here, we identify the muscle-specific ribosomal protein Rpl3l as an unexpected nuclear regulator of genome architecture in atrial cardiomyocytes. Rpl3l is enriched in the nucleus and nucleolus, where it binds its own genomic locus and stabilizes a CTCF-anchored chromatin boundary that represses the T-type calcium channel gene

Identifiers

PMID42395400
PMCPMC13320957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.