Evidence map›Paper›PMID 42395399›Full record

ArticlebioRxiv : the preprint server for biology2026

Depleting prion protein using splice-switching small molecules.

Bo Liu, Benjamin Fair, Zhiling Kuang, Zhichao Tang, Junxing Zhao, Lixian Zhou, Qingyao Kong, Aniruddhsingh Solanki, Connor Kenny, James A Mastrianni and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bo LiuSection of Genetic Medicine, Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL, USA.
Benjamin FairSection of Genetic Medicine, Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL, USA.
Zhiling KuangDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA.
Zhichao TangSection of Genetic Medicine, Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL, USA.
Junxing ZhaoSection of Genetic Medicine, Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL, USA.
Lixian ZhouSection of Genetic Medicine, Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL, USA.
Qingyao KongDepartment of Anesthesia and Critical Care, The University of Chicago, Chicago, IL, USA.
Aniruddhsingh SolankiDepartment of Neurology, Center for Comprehensive Care and Research on Memory Disorders, University of Chicago, Chicago, IL, USA.
Connor KennySection of Genetic Medicine, Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL, USA.
James A MastrianniDepartment of Neurology, Center for Comprehensive Care and Research on Memory Disorders, University of Chicago, Chicago, IL, USA.
Rui ZhaoDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA.
Yang I LiSection of Genetic Medicine, Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-0736-251X
Jingxin WangSection of Genetic Medicine, Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-9414-4093

Funding

The molecular mechanism of pre-mRNA splicingR35GM145289 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI RUI ZHAO · 2022 to 2026
$4.3M
Modulating gene expression by RNA-targeting chimerasR35GM147498 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Jingxin Wang · 2022 to 2026
$2.1M
Computational genomics approaches to study mechanisms and function of mRNA splicingR35GM153249 · NIGMS · UNIVERSITY OF CHICAGO · PI Yang Li · 2024 to 2026
$1.2M
Understanding small molecule modulation of splicing for Huntington's disease therapyR21NS142950 · NINDS · UNIVERSITY OF COLORADO DENVER · PI RUI ZHAO · 2025 to 2026
$429k
NIGMS NIH HHS R35 GM145289NIGMS NIH HHS R35 GM147498NIGMS NIH HHS R35 GM153249NINDS NIH HHS R21 NS142950
6 · The paper itself

Abstract

Prion diseases are fatal neurodegenerative disorders driven by prion protein (PrP) misfolding, and lowering cellular PrP represents a promising therapeutic strategy. Here we report a small-molecule approach that reduces PrP by modulating pre-mRNA splicing of the

Identifiers

PMID42395399
PMCPMC13320984

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.