ArticleAnnals of gastroenterological surgery2026
Differential Prognostic Impact of Prior Cholecystectomy Between Proximal and Distal Colorectal Cancer: A 12-Year Retrospective Cohort Study of 3487 Consecutive Patients.
Article in Annals of gastroenterological surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
Background: The prognostic impact of prior cholecystectomy (CCY) in patients with colorectal cancer (CRC) remains uncertain. The aim of this study was to evaluate the prognostic impact of prior CCY in a large cohort of patients with CRC, with particular attention to tumor location. Methods: We retrospectively analyzed all patients diagnosed with colorectal adenocarcinoma between January 2012 and December 2023. Patients were classified into proximal (cecum, ascending, and transverse) and distal (descending, sigmoid, and rectum) groups. Survival outcomes were compared using multivariate Cox proportional hazards regression models, including an interaction term between tumor location and history of CCY. Propensity score matching (PSM) was performed as a sensitivity analysis. Results: Among 3487 patients (1375 proximal and 2112 distal CRC), 158 (4.8%) had a history of CCY. Proximal CRC was more frequently associated with female sex, older age, history of CCY, poor differentiation, BRAF mutation, MSI-high status, and non-resection initial strategy ( Conclusions: History of CCY was associated with worse prognosis in proximal CRC but not in distal CRC, suggesting a differential impact of CCY on prognosis in CRC. Our findings would provide insight into further research on bile acid metabolism or microbiome modulation in CRC patients.
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