ArticleAnnals of gastroenterological surgery2026
Impact of Prophylactic Cefepime on Surgical Site Infection and Severe Morbidity in Patients Who Underwent Pancreaticoduodenectomy With Preoperative Biliary Drainage.
Article in Annals of gastroenterological surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Although prophylactic broad-spectrum antibiotics can reduce postoperative complications after pancreaticoduodenectomy (PD), the optimal regimen remains uncertain. This study evaluated the impact of prophylactic cefepime (CFPM) on surgical site infection (SSI) and severe morbidity after PD with preoperative biliary drainage. Methods: Among 352 patients who underwent PD from 2010 to 2023, 163 patients met the inclusion criteria. Cefmetazole (CMZ) or cefazolin (CEZ) were administered as prophylactic antibiotics before May 2016, and CFPM thereafter. Short-term outcomes were compared between patients receiving CMZ/CEZ and those receiving CFPM. Risk factors for SSI and severe morbidity were assessed by multivariate logistic regression. Results: The CFPM group ( Conclusions: Prophylactic CFPM may reduce SSIs and severe morbidity after PD with preoperative biliary drainage.
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