ReviewAnnals of gastroenterological surgery2026
Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis.
Review in Annals of gastroenterological surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting-edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract. This comprehensive review aimed to synthesize and consolidate the key clinical and translational research achievements published by our department, primarily focusing on gastric cancer (GC) and the pathophysiological mechanisms that drive its progression. Methods: We systematically reviewed the most impactful English-language original research papers from our institution, since 2005. The identified studies span critical areas including molecular carcinogenesis, tumor microenvironment (TME) components, and mechanisms of systemic metastasis and drug resistance, and so on. Results: Our accumulated research has yielded significant insights into the molecular basis of GC. A core area of contribution includes the genetic and epigenetic changes during carcinogenesis of gastric cancer or Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS), the tumor microenvironment (TME) especially focusing on Cancer-Associated Fibroblasts (CAFs), a factor promoting peritoneal dissemination of ECM-related genes and gut microbiota. Furthermore, our translational work has explored mechanisms of resistance to chemotherapeutic agents. Conclusion: The collective research from our department represents a crucial contribution to the global understanding of gastric cancer pathogenesis, progression, and clinical management. These findings underscore our commitment to translating basic scientific discoveries into actionable strategies that advance individualized therapy, ultimately improving the long-term prognosis for patients with digestive malignancies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.