ArticleAnnals of gastroenterological surgery2026
Surgical Outcomes and Recurrence Management in Borderline Resectable Hepatocellular Carcinoma: Implications for Multidisciplinary Strategies.
Article in Annals of gastroenterological surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oncological resectability classification for hepatocellular carcinoma (HCC) emphasizes the need to reassess treatment strategies for borderline resectable (BR) cases. This study evaluated surgical outcomes and prognostic factors in BR-HCC and reconsidered multidisciplinary approaches for recurrence management. Methods: The study comprised 433 patients who underwent primary hepatic resection for HCC between 2000 and 2023. Patients were classified as R, BR1, and BR2 according to the Expert Consensus Statement 2023. Multivariate Cox proportional hazard models were conducted to identify prognostic factors for disease-free and overall survival in BR (BR1 + BR2) patients. Results: Among 70 patients with BR-HCC (BR1: Conclusions: BR1 and BR2-HCC represent biologically aggressive subsets with high recurrence rates and poor prognosis, particularly in tumors with up-to-7 out status, lymph node metastasis, and macrovascular invasion. Active salvage treatment for recurrence may improve survival, highlighting the importance of multidisciplinary approaches in BR-HCC management.
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