Evidence map›Paper›PMID 42395039›Full record

ArticleWorld journal of virology2026

Continuous quality improvement, linkage to peer supporters in prevention of mother-to-child human immunodeficiency virus transmission programs in Rwanda.

Jackson Sebeza, Peter Memiah, Mariam Salim Mbwana, Hassan Fredrick Fussi, Hafidha Mhando Bakari, Upendo Kayeke Chenya, Beatrice Kelvin Mpimo, Haji Mbwana Ally, Basile Ikuzo, Habib Omari Ramadhani

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Article in World journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Jackson SebezaSchool of Public Health, College of Medicine and Health Sciences, University of Rwanda, Kigali 3286, Rwanda.
Peter MemiahDepartment of Global Health, Graduate School, University of Maryland, Baltimore, MD 21201, United States.
Mariam Salim MbwanaDepartment of Medicine, Primary Health Care Institute, Iringa 51108, Tanzania.
Hassan Fredrick FussiDepartment of Medicine, District Hospital, Dar es Salaam 35091, Tanzania.
Hafidha Mhando BakariDepartment of Literature, Communication and Publishing, University of Dar es Salaam, Dar es Salaam 35091, Tanzania.
Upendo Kayeke ChenyaDepartment of Prevention and Treatment, Drug Control and Enforcement Authority, Dar es Salaam 15103, Tanzania.
Beatrice Kelvin MpimoDepartment of Research, Lincoln University, Oakland, CA 94612, United States.
Haji Mbwana AllyDepartment of Medicine, Kilimanjaro Christian Medical Center, Moshi 25116, Kilimanjaro, Tanzania.
Basile IkuzoDivision of Human Immunodeficiency Virus, Rwanda Biomedical Center, Institute of Human Immunodeficiency Virus Disease Prevention and Control, Kigali 4285, Rwanda.
Habib Omari RamadhaniDepartment of Medicine, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, United States. homari@ihv.umaryland.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeer supporters are instrumental for the successful navigation of prevention of mother-to-child human immunodeficiency virus (HIV) transmission services, including maternal viral load suppression and early infant HIV diagnosis. These outcomes are critical for the elimination of mother-to-child HIV transmission. We assessed the impact of continuous quality improvement (CQI) services on assignment to peer supporters and undetection of the viruses among pregnant women living with HIV (WLHIV) and mother-to-child transmission of HIV (MTCT) rates among HIV exposed babies in Rwanda.

aimTo assess the impact of CQI services on assignment to peer supporters and undetection of the viruses among pregnant WLHIV and MTCT rates among HIV exposed babies in Rwanda.

methodsBetween 2021 and 2022, CQI services were implemented in 18 of the 38 healthcare facilities included in this analysis. Healthcare workers in 18 facilities used CQI approaches to key predictors of, and contributors related to, the implementation of the prevention of MTCT (PMTCT) program to improve maternal and infant outcomes. This was a secondary data analysis that explored the association between CQI and assignment to peer supporters, undetection of the virus, and MTCT rates. To assess the impact of CQI on these outcomes, a multivariable logistic regression model was used to compute adjusted odds ratios (aOR) and corresponding 95% confidence intervals (CI).

resultsA total of 1145 mother-baby pairs were included, of whom 558 (48.7%) were from facilities that implemented CQI. At the end of evaluation, 1043 (91.0%) either completed 24-months of follow-up or remained in care in the same facilities. Of 102 not available at the evaluation, 84 were transferred out, and 18 were dead or lost to follow-up. Overall, 405 (35.4%) women were assigned to peer supporters, 1004 (87.7%) had undetectable viruses, and 8 (0.7%) infants were infected with HIV. Compared to women from non-CQI facilities, those from CQI implementing facilities had 32% higher odds of being assigned to peer supporters (aOR = 1.32; 95%CI: 1.02-1.71). Similarly, disclosing HIV status (aOR = 1.53; 95%CI: 1.10-2.14) and a higher number of health care workers per 1000 active patients (> 4

conclusionNearly 3 in 10 pregnant WLHIV in Rwanda were linked to peer support to support the successful navigation of PMTCT services, and CQI increased this linkage and aided the achievement of undetectable viruses. Implementing CQI and promoting HIV status disclosure is critical to facilitate peer support linkage and improve maternal and infant outcomes.

Indexed as

Continuous quality improvementHuman immunodeficiency virusPeer support, mother to child transmission of human immunodeficiency virusPregnant women living with human immunodeficiency virusRwanda

Identifiers

PMID42395039
PMCPMC13324769

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.