ArticleJournal of ginseng research2026
20(S)-protopanaxatriol alleviates gastritis by attenuating oxidative stress and inflammatory responses via inhibition of PI3K/AKT and JAK/STAT3 pathways.
Article in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Inflammation is a fundamental protective response of the body; however, chronic or excessive inflammation can perturb immune homeostasis and elevate the risk of cardiovascular, metabolic, and oncological diseases. Protopanaxatriol (PPT), a principal bioactive metabolite of Purpose: This study aims to evaluate the anti-inflammatory potential of PPT and elucidate mechanistic pathways. Methods: Potential targets and signaling pathways were predicted using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. The anti-inflammatory activity of PPT was assessed Results: PPT markedly attenuated LPS-induced inflammatory responses at non-cytotoxic concentrations, suppressing NO production and reducing expression of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). Conclusion: PPT exerts potent anti-inflammatory effects by inhibiting PI3K/AKT and JAK-STAT3 signaling and alleviating oxidative stress. These findings support PPT as a promising candidate for the development of novel anti-inflammatory therapeutics.
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