ArticleJournal of ginseng research2026
Ginsenoside Rb2 modulates the skin barrier by targeting Src to regulate PI3K/Akt signaling in HaCaT cells.
Article in Journal of ginseng research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Ginsenoside Rb2 (G-Rb2) is a protopanaxadiol-type saponin, which is primarily enriched in the stems, leaves, and berries. G-Rb2 exhibits multiple biological effects, mainly including anti-diabetic, anti-obesity, cardiovascular protection, and anti-virus activities. However, the mechanism by which G-Rb2 regulates skin health has not been clearly elucidated. Methods: In this study, RNA sequencing (RNA-seq) was employed to analyze gene expression profiles in HaCaT cells treated with G-Rb2. Based on the bioinformatic results, HaCaT cells were treated with different concentrations of G-Rb2, and several Results: The results demonstrated that G-Rb2 exerted a pronounced skin-protective effect by activating Src and regulating skin health via the downstream PI3K/Akt signaling pathway. DFT-derived electrostatic potential and frontier orbital analyses, molecular docking, and 100-ns MD simulations collectively supported a stable binding mode of G-Rb2 to Src. Conclusion: These findings highlighted the potential of G-Rb2 as a natural functional compound for supporting skin health and preventing skin-associated disorders.
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