Evidence map›Paper›PMID 42394978›Full record

ArticleFrontiers in pharmacology2026

The tryptanthrin derivative g2 suppresses tongue squamous cell carcinoma via PI3K/AKT/P53 cathway modulation: evidence from

Jing Miao, Shijie Zhang, Mengxiang Wang, Zeng Li, Na Lv, Ming Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing Miao *Department of Stomatology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.
Shijie Zhang *Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, China.
Mengxiang WangDepartment of Stomatology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.
Zeng LiInflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, China.
Na LvDepartment of Stomatology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.
Ming SunDepartment of Stomatology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Tongue squamous cell carcinoma (TSCC) is a prevalent and aggressive oral malignancy with a poor prognosis and limited treatment options, underscoring the need for novel therapeutic agents. Tryptanthrin derivatives have shown promising anticancer potential across various cancers. This study aimed to evaluate the antitumor efficacy and elucidate the mechanism of action of a novel tryptanthrin derivative, Methods: The cytotoxic effect of Results and Discussion:

Indexed as

anti-tumorG2PI3K/Akt/P53 pathwaytryptanthrin derivativesTSCC

Identifiers

PMID42394978
PMCPMC13323819

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.